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Mouse Anti-NR2F1 Recombinant Antibody (CBWJC-4262) (CBMAB-C5619WJ)

This product is a Mouse antibody that recognizes NR2F1. This antibody CBWJC-4262 can be used for immunoassay techniques such as: WB, IHC, IP.
See all NR2F1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-4262
Antibody Isotype
IgG2a
Application
WB, IHC, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NR2F1
Introduction
The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
Entrez Gene ID
7025
UniProt ID
P10589
Alternative Names
Nuclear Receptor Subfamily 2 Group F Member 1; COUP Transcription Factor I; V-ErbA-Related Protein 3; COUP-TF I; COUP-TF1; TFCOUP1; ERBAL3; EAR-3; EAR3; Transcription Factor COUP 1 (Chicken Ovalbumin Upstream Promoter 1, V-Erb-A Homolog-Like 3);
Function
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.
Biological Process
Anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuron projection developmentIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Nervous system developmentIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus
Involvement in disease
Bosch-Boonstra-Schaaf optic atrophy syndrome (BBSOAS):
An autosomal dominant disorder characterized by optic atrophy associated with developmental delay and intellectual disability. Most patients also have evidence of cerebral visual impairment.

Ghafouri-Fard, S., Khoshbakht, T., Hussen, B. M., Baniahmad, A., Taheri, M., & Samsami, M. (2022). A review on the role of NR2F1-AS1 in the development of cancer. Pathology-Research and Practice, 154210.

Liu, Y., Chen, S., Cai, K., Zheng, D., Zhu, C., Li, L., ... & Sun, C. (2022). Hypoxia-induced long noncoding RNA NR2F1-AS1 maintains pancreatic cancer proliferation, migration, and invasion by activating the NR2F1/AKT/mTOR axis. Cell Death & Disease, 13(3), 232.

Li, D., Xu, M., Wang, Z., Huang, P., Huang, C., Chen, Z., ... & Qin, S. (2022). The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis. Cell Death & Disease, 13(1), 84.

Rodriguez-Tirado, C., Kale, N., Carlini, M. J., Shrivastava, N., Rodrigues, A. A., Khalil, B. D., ... & Sosa, M. S. (2022). NR2F1 is a barrier to dissemination of early-stage breast cancer cells. Cancer Research, 82(12), 2313-2326.

Tocco, C., Bertacchi, M., & Studer, M. (2021). Structural and functional aspects of the neurodevelopmental gene NR2F1: From animal models to human pathology. Frontiers in Molecular Neuroscience, 14, 767965.

Khalil, B. D., Sanchez, R., Rahman, T., Rodriguez-Tirado, C., Moritsch, S., Martinez, A. R., ... & Aguirre-Ghiso, J. A. (2021). An NR2F1-specific agonist suppresses metastasis by inducing cancer cell dormancy. Journal of Experimental Medicine, 219(1), e20210836.

Liu, Y., Zhang, P., Wu, Q., Fang, H., Wang, Y., Xiao, Y., ... & Hu, G. (2021). Long non-coding RNA NR2F1-AS1 induces breast cancer lung metastatic dormancy by regulating NR2F1 and ΔNp63. Nature communications, 12(1), 5232.

Bertacchi, M., Romano, A. L., Loubat, A., Tran Mau‐Them, F., Willems, M., Faivre, L., ... & Studer, M. (2020). NR2F1 regulates regional progenitor dynamics in the mouse neocortex and cortical gyrification in BBSOAS patients. The EMBO journal, 39(13), e104163.

Zhang, Y., Zheng, A., Xu, R., Zhou, F., Hao, A., Yang, H., & Yang, P. (2019). NR2F1-induced NR2F1-AS1 promotes esophageal squamous cell carcinoma progression via activating Hedgehog signaling pathway. Biochemical and biophysical research communications, 519(3), 497-504.

Gao, X. L., Zheng, M., Wang, H. F., Dai, L. L., Yu, X. H., Yang, X., ... & Tang, Y. L. (2019). NR2F1 contributes to cancer cell dormancy, invasion and metastasis of salivary adenoid cystic carcinoma by activating CXCL12/CXCR4 pathway. BMC cancer, 19(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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