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Mouse Anti-NR4A2 Recombinant Antibody (1C6) (CBMAB-N3467-WJ)

This product is a Mouse antibody that recognizes NR4A2. The antibody 1C6 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all NR4A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C6
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear receptor subfamily 4, group A, member 2
Introduction
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Nuclear Receptor Subfamily 4 Group A Member 2; Transcriptionally-Inducible Nuclear Receptor; Immediate-Early Response Protein NOT; Orphan Nuclear Receptor NURR1; NURR1; TINUR; Not; Transcriptionally Inducible Nuclear Receptor Related 1; NGFI-B/Nur77 Beta-Type Transcription Factor Homolog;
Function
Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).
Biological Process
Adult locomotory behaviorIEA:Ensembl
Canonical Wnt signaling pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Cellular response to corticotropin-releasing hormone stimulusISS:UniProtKB
Cellular response to extracellular stimulusManual Assertion Based On ExperimentIDA:MGI
Cellular response to oxidative stressIEA:Ensembl
Central nervous system neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system projection neuron axonogenesisIEA:Ensembl
Dopamine biosynthetic processIEA:Ensembl
Dopaminergic neuron differentiationISS:UniProtKB
Fat cell differentiationISS:UniProtKB
General adaptation syndromeIEA:Ensembl
Habenula developmentIEA:Ensembl
Midbrain dopaminergic neuron differentiationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of neuron apoptotic processIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Neuron maturationIEA:Ensembl
Neuron migrationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Positive regulation of catalytic activityIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Post-embryonic developmentIEA:Ensembl
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of respiratory gaseous exchangeIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to amphetamineIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Signal transduction1 PublicationNAS:ProtInc
Transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Mostly nuclear; oxidative stress promotes cytoplasmic localization.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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