NR4A2

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq]

Full Name

nuclear receptor subfamily 4, group A, member 2

Function

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity).

Biological Process

Adult locomotory behaviorIEA:Ensembl
Canonical Wnt signaling pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Cellular response to corticotropin-releasing hormone stimulusISS:UniProtKB
Cellular response to extracellular stimulusManual Assertion Based On ExperimentIDA:MGI
Cellular response to oxidative stressIEA:Ensembl
Central nervous system neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Central nervous system projection neuron axonogenesisIEA:Ensembl
Dopamine biosynthetic processIEA:Ensembl
Dopaminergic neuron differentiationISS:UniProtKB
Fat cell differentiationISS:UniProtKB
General adaptation syndromeIEA:Ensembl
Habenula developmentIEA:Ensembl
Midbrain dopaminergic neuron differentiationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Negative regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Negative regulation of neuron apoptotic processIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Neuron maturationIEA:Ensembl
Neuron migrationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Positive regulation of catalytic activityIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Post-embryonic developmentIEA:Ensembl
Regulation of dopamine metabolic processIEA:Ensembl
Regulation of respiratory gaseous exchangeIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Response to amphetamineIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Signal transduction1 PublicationNAS:ProtInc
Transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Mostly nuclear; oxidative stress promotes cytoplasmic localization.