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  • Mouse Anti-NRARP Recombinant Antibody (C-12)

Mouse Anti-NRARP Recombinant Antibody (C-12) (CBMAB-N3516-WJ)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
C-12
Application
WB, IP, IF, ELISA
Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
NOTCH Regulated Ankyrin Repeat Protein
Introduction
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).
Entrez Gene ID
Human441478
Mouse67122
Rat499745
UniProt ID
HumanQ7Z6K4
MouseQ91ZA8
RatD3Z9S9
Alternative Names
NOTCH Regulated Ankyrin Repeat Protein;
Function
Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719).
During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).
Biological Process
Blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIBA:GO_Central
Branching involved in blood vessel morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of Notch signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Negative regulation of Notch signaling pathway involved in somitogenesisIEA:Ensembl
Negative regulation of T cell differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Somite rostral/caudal axis specificationIEA:Ensembl

Poodineh, J., Sirati‐Sabet, M., Rajabibazl, M., Ghasemian, M., & Mohammadi‐Yeganeh, S. (2022). Downregulation of NRARP exerts anti‐tumor activities in the breast tumor cells depending on Wnt/β‐catenin‐mediated signals: The role of miR‐130a‐3p. Chemical Biology & Drug Design, 100(3), 334-345.

Rajabibazl, M., Poodineh, J., Sirati-Sabet, M., & Mohammadi-Yeganeh, S. (2022). Downregulation of NRARP exerts anti-tumor activities in the breast tumor cells depending on Wnt/ꞵ-catenin mediated signals; the role of miR-130a-3p.

Pinto, I., Duque, M., Gonçalves, J., Akkapeddi, P., Oliveira, M. L., Cabrita, R., ... & Fragoso, R. (2020). NRARP displays either pro-or anti-tumoral roles in T-cell acute lymphoblastic leukemia depending on Notch and Wnt signaling. Oncogene, 39(5), 975-986.

John, A. A., Prakash, R., & Singh, D. (2019). miR-487b-3p impairs osteoblastogenesis by targeting Notch-regulated ankyrin-repeat protein (Nrarp). Journal of Endocrinology, 241(3), 249-263.

Jarrett, S. M., Seegar, T. C., Andrews, M., Adelmant, G., Marto, J. A., Aster, J. C., & Blacklow, S. C. (2019). Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Science signaling, 12(606), eaay2369.

Jarrett, S. M., Seegar, T. C., Andrews, M., Adelmant, G., Marto, J. A., Aster, J. C., & Blacklow, S. C. (2019). Molecular basis for feedback inhibition of Notch signaling by the Notch regulated ankyrin repeat protein NRARP. bioRxiv, 645937.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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