NRARP

Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and downregulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).

Full Name

NOTCH Regulated Ankyrin Repeat Protein

Function

Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719).
During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity).

Biological Process

Blood vessel endothelial cell proliferation involved in sprouting angiogenesisManual Assertion Based On ExperimentIBA:GO_Central
Branching involved in blood vessel morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of Notch signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Negative regulation of Notch signaling pathway involved in somitogenesisIEA:Ensembl
Negative regulation of T cell differentiationIEA:Ensembl
Negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Notch signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:MGI
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Somite rostral/caudal axis specificationIEA:Ensembl