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Mouse Anti-NRBF2 Recombinant Antibody (V2-177993) (CBMAB-N3525-WJ)

This product is a Mouse antibody that recognizes NRBF2. The antibody 1A2 can be used for immunoassay techniques such as: WB .
See all NRBF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-177993
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nuclear Receptor Binding Factor 2
Introduction
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
Entrez Gene ID
29982
UniProt ID
Q96F24
Alternative Names
Nuclear Receptor Binding Factor 2; Comodulator Of PPAR And RXR 1; Comodulator Of PPAR And RXR 2; NRBF-2; COPR; Nuclear Receptor-Binding Factor 2; Comodulator Of PPAR And RXR; COPR1; COPR2;
Function
May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).
Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657).
Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity).
Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043).
May be involved in autophagosome biogenesis (PubMed:25086043).
May play a role in neural progenitor cell survival during differentiation (By similarity).
Biological Process
AutophagyManual Assertion Based On ExperimentIMP:GO_Central
Regulation of lipid kinase activityIEA:Ensembl
Response to endoplasmic reticulum stressIEA:Ensembl
Cellular Location
Nucleus
Cytoplasm
Cytoplasmic vesicle
Cytoplasmic vesicle, autophagosome

Zhang, S. Q., Deng, Q., Zhu, Q., Hu, Z. L., Long, L. H., Wu, P. F., ... & Chen, J. G. (2023). Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression. Cell Discovery, 9(1), 90.

Wu, M. Y., Cai, C. Z., Yang, C., Yue, Z., Chen, Y., Bian, Z. X., ... & Lu, J. H. (2022). Emerging roles of NRBF2/PI3KC3 axis in maintaining homeostasis of brain and guts. Neural Regeneration Research, 17(2), 323.

Kim, J., Kang, H., Son, B., Kim, M. J., Kang, J., Park, K. H., ... & Youn, B. (2022). NRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma. Experimental & Molecular Medicine, 54(11), 1872-1885.

Shen, W., Luo, P., Sun, Y., Zhang, W., Zhou, N., Zhan, H., ... & Wei, T. (2022). NRBF2 regulates the chemoresistance of small cell lung cancer by interacting with the P62 protein in the autophagy process. Iscience, 25(6).

Wu, M. Y., Liu, L., Wang, E. J., Xiao, H. T., Cai, C. Z., Wang, J., ... & Lu, J. H. (2021). PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation. Autophagy, 17(5), 1096-1111.

Ohashi, Y. (2021). Class III phosphatidylinositol 3-kinase complex I subunit NRBF2/Atg38-from cell and structural biology to health and disease. Autophagy, 17(12), 3897-3907.

Zeng, H., Chen, H., Li, M., Zhuang, J., Peng, Y., Zhou, H., ... & Chen, G. (2021). Autophagy protein NRBF2 attenuates endoplasmic reticulum stress-associated neuroinflammation and oxidative stress via promoting autophagosome maturation by interacting with Rab7 after SAH. Journal of Neuroinflammation, 18(1), 1-16.

Cai, C. Z., Yang, C., Zhuang, X. X., Yuan, N. N., Wu, M. Y., Tan, J. Q., ... & Lu, J. H. (2021). NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy, 17(5), 1112-1130.

Ouyang, X., Ahmad, I., Johnson, M. S., Redmann, M., Craver, J., Wani, W. Y., ... & Zhang, J. (2020). Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory. Laboratory Investigation, 100(9), 1238-1251.

Lachance, V., Wang, Q., Sweet, E., Choi, I., Cai, C. Z., Zhuang, X. X., ... & Yue, Z. (2019). Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice. Molecular neurodegeneration, 14(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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