Rabbit Anti-NRG3 Recombinant Antibody (CBWJN-1550) (CBMAB-N3587-WJ)

This product is a Rabbit antibody that recognizes NRG3. The antibody CBWJN-1550 can be used for immunoassay techniques such as: WB, FC.
See all NRG3 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Mouse, Rat, Human

Clone

CBWJN-1550

Antibody Isotype

IgG

Application

WB, FC

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Neuregulin 3

Introduction

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

Entrez Gene ID

Human	10718
Mouse	18183
Rat	498596

UniProt ID

Human	P56975
Mouse	O35181
Rat	F1M182

Alternative Names

Neuregulin 3; Pro-NRG3; Pro-Neuregulin-3, Membrane-Bound Isoform; Neuregulin-3-Like Polypeptide; Neuregulin 3 Variant 10; Neuregulin 3 Variant 11; Neuregulin 3 Variant 12; Neuregulin 3 Variant 13; Neuregulin 3 Variant 14; Neuregulin 3 Variant 1;

Function

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.

Biological Process

Animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Chemorepulsion involved in interneuron migration from the subpallium to the cortexIEA:Ensembl
ERBB4 signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Mammary placode formationIEA:Ensembl
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIMP:SynGO
Negative regulation of neuron migrationIEA:Ensembl
Pattern specification processIEA:Ensembl
Regulation of cell growth1 PublicationNAS:UniProtKB

Cellular Location

Pro-neuregulin-3, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-3
Secreted
Isoform 3
Cell membrane
Isoform 3 is also proteolytically released as a soluble form.

Topology

Extracellular: 1-360
Helical: 361-381
Cytoplasmic: 382-720

PTM

Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage (By similarity).
Isoform 3 is glycosylated.

References

Ahmad, T., Vullhorst, D., Chaudhuri, R., Guardia, C. M., Chaudhary, N., Karavanova, I., ... & Buonanno, A. (2022). Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3. Journal of Cell Biology, 221(7), e202110167.

Zhou, Y., Li, Y., Meng, Y., Wang, J., Wu, F., Ning, Y., ... & Zhang, X. Y. (2020). Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia. Translational Psychiatry, 10(1), 62.

Rahman-Enyart, A., Lai, C., & Prieto, A. L. (2020). Neuregulins 1, 2, and 3 promote early neurite outgrowth in ErbB4-expressing cortical GABAergic interneurons. Molecular Neurobiology, 57(8), 3568-3588.

Rahman, A., Weber, J., Labin, E., Lai, C., & Prieto, A. L. (2019). Developmental expression of neuregulin‐3 in the rat central nervous system. Journal of Comparative Neurology, 527(4), 797-817.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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