• Home
  • NRG3
  • Rabbit Anti-NRG3 Recombinant Antibody (CBWJN-1550)

Rabbit Anti-NRG3 Recombinant Antibody (CBWJN-1550) (CBMAB-N3587-WJ)

See all NRG3 antibodies
Go to compare Compare Online Inquiry
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Rabbit
Clone
CBWJN-1550
Application
WB, FC
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Neuregulin 3
Introduction
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Entrez Gene ID
Human10718
Mouse18183
Rat498596
UniProt ID
HumanP56975
MouseO35181
RatF1M182
Alternative Names
Neuregulin 3; Pro-NRG3; Pro-Neuregulin-3, Membrane-Bound Isoform; Neuregulin-3-Like Polypeptide; Neuregulin 3 Variant 10; Neuregulin 3 Variant 11; Neuregulin 3 Variant 12; Neuregulin 3 Variant 13; Neuregulin 3 Variant 14; Neuregulin 3 Variant 1;
Function
Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes.
Biological Process
Animal organ developmentManual Assertion Based On ExperimentIBA:GO_Central
Chemorepulsion involved in interneuron migration from the subpallium to the cortexIEA:Ensembl
ERBB4 signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Mammary placode formationIEA:Ensembl
Modulation of chemical synaptic transmissionManual Assertion Based On ExperimentIMP:SynGO
Negative regulation of neuron migrationIEA:Ensembl
Pattern specification processIEA:Ensembl
Regulation of cell growth1 PublicationNAS:UniProtKB
Cellular Location
Pro-neuregulin-3, membrane-bound isoform
Cell membrane
Does not seem to be active.
Neuregulin-3
Secreted
Isoform 3
Cell membrane
Isoform 3 is also proteolytically released as a soluble form.
Topology
Extracellular: 1-360
Helical: 361-381
Cytoplasmic: 382-720
PTM
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.
Extensive glycosylation precedes the proteolytic cleavage (By similarity).
Isoform 3 is glycosylated.

Ahmad, T., Vullhorst, D., Chaudhuri, R., Guardia, C. M., Chaudhary, N., Karavanova, I., ... & Buonanno, A. (2022). Transcytosis and trans-synaptic retention by postsynaptic ErbB4 underlie axonal accumulation of NRG3. Journal of Cell Biology, 221(7), e202110167.

Zhou, Y., Li, Y., Meng, Y., Wang, J., Wu, F., Ning, Y., ... & Zhang, X. Y. (2020). Neuregulin 3 rs10748842 polymorphism contributes to the effect of body mass index on cognitive impairment in patients with schizophrenia. Translational Psychiatry, 10(1), 62.

Rahman-Enyart, A., Lai, C., & Prieto, A. L. (2020). Neuregulins 1, 2, and 3 promote early neurite outgrowth in ErbB4-expressing cortical GABAergic interneurons. Molecular Neurobiology, 57(8), 3568-3588.

Rahman, A., Weber, J., Labin, E., Lai, C., & Prieto, A. L. (2019). Developmental expression of neuregulin‐3 in the rat central nervous system. Journal of Comparative Neurology, 527(4), 797-817.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-NRG3 Recombinant Antibody (CBWJN-1550)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry