Mouse Anti-NRP1 Recombinant Antibody (A1396) (CBMAB-AP12602LY)

Neuropilin 1

This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Neuropilin 1; Vascular Endothelial Cell Growth Factor 165 Receptor; VEGF165R; NRP; Transmembrane Receptor; CD304 Antigen;

E-AB-27265

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:BHF-UCL
AngiogenesisManual Assertion Based On ExperimentIMP:BHF-UCL
Angiogenesis involved in coronary vascular morphogenesisBy SimilarityISS:BHF-UCL
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Artery morphogenesisBy SimilarityISS:BHF-UCL
Axon extension involved in axon guidanceISS:BHF-UCL
Axon guidanceManual Assertion Based On ExperimentTAS:ProtInc
Axonal fasciculationIEA:Ensembl
Axonogenesis involved in innervationISS:BHF-UCL
Basal dendrite arborizationBy SimilarityISS:ARUK-UCL
Basal dendrite developmentBy SimilarityISS:ARUK-UCL
Branching involved in blood vessel morphogenesisBy SimilarityISS:BHF-UCL
Branchiomotor neuron axon guidanceIEA:Ensembl
Cell migration involved in sprouting angiogenesisISS:BHF-UCL
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to hepatocyte growth factor stimulusManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular response to vascular endothelial growth factor stimulusBy SimilarityISS:BHF-UCL
Commissural neuron axon guidanceISS:BHF-UCL
Coronary artery morphogenesisIEA:Ensembl
Dichotomous subdivision of terminal units involved in salivary gland branchingIEA:Ensembl
Dorsal root ganglion morphogenesisIEA:Ensembl
Endothelial cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Endothelial cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Endothelial tip cell fate specificationISS:BHF-UCL
Facial nerve structural organizationIEA:Ensembl
Facioacoustic ganglion developmentIEA:Ensembl
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Hepatocyte growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Motor neuron migrationISS:UniProtKB
Negative regulation of axon extension involved in axon guidanceIEA:Ensembl
Negative regulation of extrinsic apoptotic signaling pathwayIEA:Ensembl
Negative regulation of neuron apoptotic processIEA:Ensembl
Nerve developmentISS:BHF-UCL
Neural crest cell migration involved in autonomic nervous system developmentISS:BHF-UCL
Neuron migrationISS:BHF-UCL
Neuropilin signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Otic placode developmentIEA:Ensembl
Outflow tract septum morphogenesisISS:BHF-UCL
Platelet-derived growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive chemotaxisISS:BHF-UCL
Positive regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of angiogenesisIEA:Ensembl
Positive regulation of axon extension involved in axon guidanceISS:BHF-UCL
Positive regulation of cell migration involved in sprouting angiogenesisIEA:Ensembl
Positive regulation of cytokine activityManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeBy SimilarityISS:BHF-UCL
Positive regulation of filopodium assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of focal adhesion assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of retinal ganglion cell axon guidanceISS:BHF-UCL
Positive regulation of smooth muscle cell migrationManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:BHF-UCL
Postsynapse organizationIEA:Ensembl
Protein localization to early endosomeBy SimilarityISS:BHF-UCL
Regulation of Cdc42 protein signal transductionManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of retinal ganglion cell axon guidanceISS:BHF-UCL
Regulation of vesicle-mediated transportManual Assertion Based On ExperimentTAS:BHF-UCL
Renal artery morphogenesisIEA:Ensembl
Retina vasculature morphogenesis in camera-type eyeBy SimilarityISS:BHF-UCL
Retinal ganglion cell axon guidanceISS:BHF-UCL
Semaphorin-plexin signaling pathway1 PublicationNAS:BHF-UCL
Semaphorin-plexin signaling pathway involved in axon guidanceIEA:Ensembl
Semaphorin-plexin signaling pathway involved in neuron projection guidanceISS:BHF-UCL
Sensory neuron axon guidanceIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Sprouting angiogenesisBy SimilarityISS:BHF-UCL
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIMP:BHF-UCL
Substrate-dependent cell migration, cell extensionManual Assertion Based On ExperimentIMP:BHF-UCL
Sympathetic ganglion developmentISS:BHF-UCL
Sympathetic neuron projection extensionISS:BHF-UCL
Sympathetic neuron projection guidanceISS:BHF-UCL
Toxin transportIEA:Ensembl
Trigeminal ganglion developmentIEA:Ensembl
Trigeminal nerve structural organizationIEA:Ensembl
Vascular endothelial growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
VEGF-activated neuropilin signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
VEGF-activated neuropilin signaling pathway involved in axon guidanceIEA:Ensembl
Ventral trunk neural crest cell migrationIEA:Ensembl
Vestibulocochlear nerve structural organizationIEA:Ensembl
Viral entry into host cellManual Assertion Based On ExperimentIDA:UniProtKB

Isoform 2
Secreted
Mitochondrion membrane
Cell membrane
Cytoplasm

Extracellular: 22-856
Helical: 857-879
Cytoplasmic: 880-923