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Mouse Anti-NSMCE3 Recombinant Antibody (4F7) (CBMAB-N3669-WJ)

This product is a Mouse antibody that recognizes NSMCE3. The antibody 4F7 can be used for immunoassay techniques such as: ELISA, WB.
See all NSMCE3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4F7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT
Introduction
The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]
Entrez Gene ID
56160
UniProt ID
Q96MG7
Alternative Names
NSE3 Homolog, SMC5-SMC6 Complex Component; Hepatocellular Carcinoma-Associated Protein 4; Necdin-Like 2, SMC5-SMC6 Complex Component; Melanoma-Associated Antigen G1; Non-SMC Element 3 Homolog; Necdin-Like Protein 2; MAGE-G1 Antigen; MAGEG1; NDNL2; HCA4;
Function
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983).
The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041).
May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).
Biological Process
Cellular response to hydroxyureaManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to radiationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to UVManual Assertion Based On ExperimentIMP:UniProtKB
DNA repairManual Assertion Based On ExperimentIMP:UniProtKB
Double-strand break repair via homologous recombination1 PublicationIC:ComplexPortal
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein sumoylation1 PublicationIC:ComplexPortal
Regulation of growthIEA:UniProtKB-KW
Regulation of telomere maintenance1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Chromosome, telomere
Involvement in disease
Lung disease, immunodeficiency, and chromosome breakage syndrome (LICS):
An autosomal recessive chromosome breakage syndrome associated with severe, fatal lung disease in early childhood, following viral pneumonia. LICS is characterized by combined T and B-cell immunodeficiency. Some patients may have mild dysmorphic features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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