Mouse Anti-NSMCE3 Recombinant Antibody (4F7) (CBMAB-N3669-WJ)

Name: Mouse Anti-NSMCE3 Recombinant Antibody (4F7)
SKU: CBMAB-N3669-WJ
Rating: 5 (1 reviews)

See all NSMCE3 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F7

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.4

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT

Introduction

The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]

Entrez Gene ID

56160

UniProt ID

Q96MG7

Alternative Names

NSE3 Homolog, SMC5-SMC6 Complex Component; Hepatocellular Carcinoma-Associated Protein 4; Necdin-Like 2, SMC5-SMC6 Complex Component; Melanoma-Associated Antigen G1; Non-SMC Element 3 Homolog; Necdin-Like Protein 2; MAGE-G1 Antigen; MAGEG1; NDNL2; HCA4;

Function

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983).
The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041).
May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).

Biological Process

Cellular response to hydroxyureaManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to radiationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to UVManual Assertion Based On ExperimentIMP:UniProtKB
DNA repairManual Assertion Based On ExperimentIMP:UniProtKB
Double-strand break repair via homologous recombination1 PublicationIC:ComplexPortal
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein sumoylation1 PublicationIC:ComplexPortal
Regulation of growthIEA:UniProtKB-KW
Regulation of telomere maintenance1 PublicationIC:ComplexPortal

Cellular Location

Cytoplasm
Nucleus
Chromosome, telomere

Involvement in disease

Lung disease, immunodeficiency, and chromosome breakage syndrome (LICS):
An autosomal recessive chromosome breakage syndrome associated with severe, fatal lung disease in early childhood, following viral pneumonia. LICS is characterized by combined T and B-cell immunodeficiency. Some patients may have mild dysmorphic features.

Abellard, A., Stephen, E., & Mahdavinia, M. (2022). RECURRENT LUNG INFECTIONS IN A HETEROZYGOUS CARRIER OF NOVEL NSMCE3 MUTATION. Annals of Allergy, Asthma & Immunology, 129(5), S125-S126.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-NSMCE3 Recombinant Antibody (4F7)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Anti-NSMCE3 Recombinant Antibody (4F7) (CAT#: CBMAB-A5831-LY)

Related Products

Mouse Anti-NSMCE3 Recombinant Antibody (4F7) (CAT#: CBMAB-A5831-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry