Sign in or Register   Sign in or Register
  |  

NSMCE3

The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene.
Full Name
NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT
Function
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983).
The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041).
May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity).
Biological Process
Cellular response to hydroxyureaManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to radiationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to UVManual Assertion Based On ExperimentIMP:UniProtKB
DNA repairManual Assertion Based On ExperimentIMP:UniProtKB
Double-strand break repair via homologous recombination1 PublicationIC:ComplexPortal
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Protein sumoylation1 PublicationIC:ComplexPortal
Regulation of growthIEA:UniProtKB-KW
Regulation of telomere maintenance1 PublicationIC:ComplexPortal
Cellular Location
Cytoplasm
Nucleus
Chromosome, telomere
Involvement in disease
Lung disease, immunodeficiency, and chromosome breakage syndrome (LICS):
An autosomal recessive chromosome breakage syndrome associated with severe, fatal lung disease in early childhood, following viral pneumonia. LICS is characterized by combined T and B-cell immunodeficiency. Some patients may have mild dysmorphic features.

Anti-NSMCE3 antibodies

Loading...
Target: NSMCE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F7
Application*: WB, E
Target: NSMCE3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F7
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare