Mouse Anti-NTNG2 Recombinant Antibody (4F11) (CBMAB-N0553-WJ)

Name: Mouse Anti-NTNG2 Recombinant Antibody (4F11)
SKU: CBMAB-N0553-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F11

Application

ELISA, WB, IHC

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

netrin G2

Introduction

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Entrez Gene ID

84628

UniProt ID

Q96CW9

Alternative Names

Netrin G2; Netrin G1; Netrin-G2; Lmnt2; BA479K20.1 (Novel Protein); BA479K20.1;

Function

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
AxonogenesisISS:UniProtKB
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionIEA:Ensembl
Postsynaptic specialization assemblyIEA:Ensembl
Regulation of neuron migrationISS:UniProtKB
Regulation of neuron projection arborizationISS:UniProtKB
Regulation of neuron projection developmentISS:UniProtKB
Regulation of presynapse assemblyIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionIEA:Ensembl
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia (NEDBASH):
An autosomal recessive disorder characterized by global developmental delay with severely impaired intellectual development, impaired motor development, axial and peripheral hypotonia, poor speech and significant behavioral abnormalities, including autism spectrum disorder, hyperactivity, mood disorders, aggression, hand and face stereotypies, sleep disturbances, anxiety, self-injurious behavior, and bruxism.

PTM

N-glycosylated.

Akif, A. Y. A. Z., & Yuluğ, B. (2022). NTNG2 Mutation: A candidate gene for a new brain-skin disorder with early neuropsychiatric manifestation? An analysis based on 3000 patients. Acta Medica Alanya, 6(1), 93-99.

Ramanan, V. K., Wang, X. K., Przybelski, S. A., Pillai, S. K. R., Kosel, M. L., Batzler, A. K., ... & Vemuri, P. (2020). Genome‐wide association study of tau‐PET: Association of variant near NTNG2 with resistance to tau deposition: Neuroimaging: Imaging genetics. Alzheimer's & Dementia, 16, e044321.

Abu-Libdeh, B., Ashhab, M., Shahrour, M., Daana, M., Dudin, A., Elpeleg, O., ... & Harel, T. (2019). Homozygous frameshift variant in NTNG2, encoding a synaptic cell adhesion molecule, in individuals with developmental delay, hypotonia, and autistic features. neurogenetics, 20, 209-213.

Dias, C. M., Punetha, J., Zheng, C., Mazaheri, N., Rad, A., Efthymiou, S., ... & Maroofian, R. (2019). Homozygous missense variants in NTNG2, encoding a presynaptic netrin-G2 adhesion protein, lead to a distinct neurodevelopmental disorder. The American Journal of Human Genetics, 105(5), 1048-1056.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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