NTNG2

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Full Name

netrin G2

Function

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
AxonogenesisISS:UniProtKB
Basement membrane assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionIEA:Ensembl
Postsynaptic specialization assemblyIEA:Ensembl
Regulation of neuron migrationISS:UniProtKB
Regulation of neuron projection arborizationISS:UniProtKB
Regulation of neuron projection developmentISS:UniProtKB
Regulation of presynapse assemblyIEA:Ensembl
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Synaptic membrane adhesionIEA:Ensembl
Tissue developmentManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia (NEDBASH):
An autosomal recessive disorder characterized by global developmental delay with severely impaired intellectual development, impaired motor development, axial and peripheral hypotonia, poor speech and significant behavioral abnormalities, including autism spectrum disorder, hyperactivity, mood disorders, aggression, hand and face stereotypies, sleep disturbances, anxiety, self-injurious behavior, and bruxism.

PTM

N-glycosylated.