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Mouse Anti-NUBP1 Recombinant Antibody (H-4) (CBMAB-N3831-WJ)

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Basic Information

Host Animal
Mouse
Clone
H-4
Application
WB, IP, IF, ELISA
Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
nucleotide binding protein 1 (MinD homolog, E. coli)
Introduction
NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
4682
UniProt ID
P53384
Alternative Names
Nucleotide Binding Protein 1; Nucleotide Binding Protein 1 (MinD Homolog, E. Coli); Nucleotide Binding Protein 1 (E.Coli MinD Like); NBP 1; NBP1; NBP;
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874).
Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874).
The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874).
Implicated in the regulation of centrosome duplication (By similarity).
Negatively regulates cilium formation and structure (By similarity).
Biological Process
Cell projection organizationIEA:UniProtKB-KW
Cellular iron ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Centrosome localizationIEA:Ensembl
Iron-sulfur cluster assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of centrosome duplicationIEA:Ensembl
Protein localization to cell cortexIEA:Ensembl
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Cell projection
Cytoplasm, cytoskeleton, cilium axoneme
Cytoplasm, cytoskeleton, cilium basal body
Cytoplasm, cytoskeleton, microtubule organizing center
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1.

Bargagna, B., Matteucci, S., Ciofi‐Baffoni, S., Camponeschi, F., & Banci, L. (2023). Unraveling the mechanism of [4Fe‐4S] cluster assembly on the N‐terminal cluster binding site of NUBP1. Protein Science, 32(5), e4625.

Camponeschi, F., Prusty, N. R., Heider, S. A. E., Ciofi-Baffoni, S., & Banci, L. (2020). GLRX3 acts as a [2Fe–2S] cluster chaperone in the cytosolic iron–sulfur assembly machinery transferring [2Fe–2S] clusters to NUBP1. Journal of the American Chemical Society, 142(24), 10794-10805.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-NUBP1 Recombinant Antibody (2B11) (CAT#: CBMAB-N3829-WJ)

Mouse Anti-NUBP1 Recombinant Antibody (C-7) (CAT#: CBMAB-N3830-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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