NUBP1

NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM

Full Name

nucleotide binding protein 1 (MinD homolog, E. coli)

Function

Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874).
Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874).
The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874).
Implicated in the regulation of centrosome duplication (By similarity).
Negatively regulates cilium formation and structure (By similarity).

Biological Process

Cell projection organizationIEA:UniProtKB-KW
Cellular iron ion homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Centrosome localizationIEA:Ensembl
Iron-sulfur cluster assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of centrosome duplicationIEA:Ensembl
Protein localization to cell cortexIEA:Ensembl
Regulation of cell growthManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Cell projection
Cytoplasm, cytoskeleton, cilium axoneme
Cytoplasm, cytoskeleton, cilium basal body
Cytoplasm, cytoskeleton, microtubule organizing center
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1.