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Mouse Anti-NUCKS1 Recombinant Antibody (3G10) (CBMAB-N3854-WJ)

This product is a Mouse antibody that recognizes NUCKS1. The antibody 3G10 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all NUCKS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G10
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nuclear casein kinase and cyclin-dependent kinase substrate 1
Introduction
This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle. [provided by RefSeq, Aug 2010]
Entrez Gene ID
64710
UniProt ID
Q9H1E3
Alternative Names
Nuclear Casein Kinase And Cyclin Dependent Kinase Substrate 1; NUCKS; P1; Nuclear Ubiquitous Casein Kinase And Cyclin-Dependent Kinase Substrate; Nuclear Ubiquitous Casein And Cyclin-Dependent Kinase Substrate 1; Potential LAG1 Interactor; JC7;
Function
Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318).
Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318).
Biological Process
Cellular glucose homeostasisISS:ParkinsonsUK-UCL
Cellular response to X-rayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Chromatin organizationISS:ParkinsonsUK-UCL
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Gene conversion1 PublicationNAS:ParkinsonsUK-UCL
Interstrand cross-link repairManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Modulation by host of RNA binding by virusManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Modulation by host of viral RNA-binding transcription factor activityManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation by host of viral genome replicationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation by host of viral transcriptionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of DNA strand elongationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of insulin receptor signaling pathwayISS:ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase IIIC:ParkinsonsUK-UCL
Release from viral latencyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Replication fork processingManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Cellular Location
Nucleus
Chromosome
PTM
Phosphorylated in an ATM-dependent manner in response to DNA damage (PubMed:26323318).
Phosphorylated by CDK1 and casein kinase (PubMed:11298763).

Li, B., Chen, B., Wang, X., Xiao, M., Zhang, K., Ye, W., ... & Zhang, Y. (2023). Roles of increased NUCKS1 expression in endometriosis. BMC Women's Health, 23(1), 432.

Zheng, S., Ji, R., He, H., Li, N., Han, C., Han, J., ... & Zhao, W. (2023). NUCKS1, a LINC00629-upregulated gene, facilitated osteosarcoma progression and metastasis by elevating asparagine synthesis. Cell Death & Disease, 14(8), 489.

Liao-Liao, Z. H. U., Jing-Jie, S. H. I., Yong-Dong, G. U. O., Cheng, Y. A. N. G., Rong-Lin, W. A. N. G., Shan-Shan, L. I., ... & Hai-Chuan, S. U. (2023). NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway. Neoplasma, 70(2).

Zhang, X., Zhang, X., Li, X., Bao, H., Li, G., Li, N., ... & Dou, J. (2023). NUCKS1 acts as a promising novel biomarker for the prognosis of patients with hepatocellular carcinoma. Cancer Biotherapy & Radiopharmaceuticals, 38(10), 720-725.

Hume, S., Grou, C. P., Lascaux, P., D’Angiolella, V., Legrand, A. J., Ramadan, K., & Dianov, G. L. (2021). The NUCKS1-SKP2-p21/p27 axis controls S phase entry. Nature communications, 12(1), 6959.

Zhao, S., Wang, B., Ma, Y., Kuang, J., Liang, J., & Yuan, Y. (2020). NUCKS1 promotes proliferation, invasion and migration of non-small cell lung cancer by upregulating CDK1 expression. Cancer Management and Research, 13311-13323.

Maranon, D. G., Sharma, N., Huang, Y., Selemenakis, P., Wang, M., Altina, N., ... & Wiese, C. (2020). NUCKS1 promotes RAD54 activity in homologous recombination DNA repair. Journal of Cell Biology, 219(10), e201911049.

Huang, Y. K., Kang, W. M., Ma, Z. Q., Liu, Y. Q., Zhou, L., & Yu, J. C. (2019). NUCKS1 promotes gastric cancer cell aggressiveness by upregulating IGF-1R and subsequently activating the PI3K/Akt/mTOR signaling pathway. Carcinogenesis, 40(2), 370-379.

Yuan, X., Zhang, M., Ao, J., Zhen, Z., Gao, X., & Li, M. (2019). NUCKS1 is a novel regulator of milk synthesis in and proliferation of mammary epithelial cells via the mTOR signaling pathway. Journal of Cellular Physiology, 234(9), 15825-15835.

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For research use only. Not intended for any clinical use.

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