NUCKS1

This gene encodes a nuclear protein that is highly conserved in vertebrates. The conserved regions of the protein contain several consensus phosphorylation sites for casein kinase II and cyclin-dependent kinases, two putative nuclear localization signals, and a basic DNA-binding domain. It is phosphorylated in vivo by Cdk1 during mitosis of the cell cycle.

Full Name

nuclear casein kinase and cyclin-dependent kinase substrate 1

Function

Chromatin-associated protein involved in DNA repair by promoting homologous recombination (HR) (PubMed:26323318).
Binds double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures, but with less affinity than RAD51AP1 (PubMed:26323318).

Biological Process

Cellular glucose homeostasisISS:ParkinsonsUK-UCL
Cellular response to X-rayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Chromatin organizationISS:ParkinsonsUK-UCL
Double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Gene conversion1 PublicationNAS:ParkinsonsUK-UCL
Interstrand cross-link repairManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Modulation by host of RNA binding by virusManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Modulation by host of viral RNA-binding transcription factor activityManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation by host of viral genome replicationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Positive regulation by host of viral transcriptionManual Assertion Based On ExperimentIGI:ParkinsonsUK-UCL
Positive regulation of insulin receptor signaling pathwayIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Regulation of DNA replicationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of DNA strand elongationManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Regulation of insulin receptor signaling pathwayISS:ParkinsonsUK-UCL
Regulation of transcription by RNA polymerase IIIC:ParkinsonsUK-UCL
Release from viral latencyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Replication fork processingManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL

Cellular Location

Nucleus
Chromosome

PTM

Phosphorylated in an ATM-dependent manner in response to DNA damage (PubMed:26323318).
Phosphorylated by CDK1 and casein kinase (PubMed:11298763).