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Mouse Anti-NUDT18 Recombinant Antibody (5D7) (CBMAB-N3887-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
5D7
Antibody Isotype
IgG1
Application
WB, FC, IHC, IF, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.55 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nudix Hydrolase 18
Introduction
The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Entrez Gene ID
79873
UniProt ID
Q6ZVK8
Alternative Names
Nudix Hydrolase 18; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 18; Nucleoside Diphosphate-Linked Moiety X Motif 18; 7,8-Dihydro-8-Oxoguanine Phosphatase; 2-Hydroxy-DADP Phosphatase; MutT Human Homolog 3; MutT Homolog 3;
Function
Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Biological Process
dADP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
dGDP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
GDP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Nucleobase-containing small molecule metabolic processTAS:Reactome
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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