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NUDT18

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This protein contains a Nudix hydrolase domain and hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates. [provided by RefSeq, Sep 2012]
Full Name
Nudix Hydrolase 18
Function
Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools.
Biological Process
dADP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
dGDP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
GDP catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Nucleobase-containing small molecule metabolic processTAS:Reactome
Cellular Location
Cytosol
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Anti-NUDT18 antibodies

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Mouse Anti-NUDT18 Recombinant Antibody (5F9) (CBMAB-N3888-WJ)

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Target: NUDT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F9
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-NUDT18 Recombinant Antibody (5D7) (CBMAB-N3887-WJ)

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Target: NUDT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D7
Application*: WB, F, IH, IF, P
Datasheet SDS

Mouse Anti-NUDT18 Recombinant Antibody (1B4) (CBMAB-N3886-WJ)

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Target: NUDT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B4
Application*: F, WB
Datasheet SDS

Mouse Anti-NUDT18 Recombinant Antibody (1A8) (CBMAB-N3885-WJ)

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Target: NUDT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A8
Application*: WB
Datasheet SDS

Mouse Anti-NUDT18 Recombinant Antibody (1A5) (CBMAB-N3884-WJ)

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Target: NUDT18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A5
Application*: F, IF, IH, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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