Mouse Anti-NUDT4 Recombinant Antibody (2F2) (CBMAB-N3907-WJ)

Name: Mouse Anti-NUDT4 Recombinant Antibody (2F2)
SKU: CBMAB-N3907-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2F2

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 4

Introduction

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]

Entrez Gene ID

11163

UniProt ID

Q9NZJ9

Alternative Names

Nudix Hydrolase 4; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4; Diphosphoinositol Polyphosphate Phosphohydrolase Type 2; Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 2; DIPP-2; DIPP2; Diphosphoinositol Polyphosphate Phosphohydrolase 2; Nucleoside Diphosphate-Linked Moiety X Motif 4;

Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170).
Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170).
Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).

Biological Process

Adenosine 5'-(hexahydrogen pentaphosphate) catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Calcium-mediated signalingManual Assertion Based On ExperimentTAS:UniProtKB
Cyclic-nucleotide-mediated signalingManual Assertion Based On ExperimentTAS:UniProtKB
Diadenosine hexaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine pentaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diphosphoinositol polyphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transduction1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm

Yuan, H., Chen, C., Li, H., Qu, G., Chen, L., Liu, Y., ... & He, Y. (2024). Role of a novel circRNA-CGNL1 in regulating pancreatic cancer progression via NUDT4–HDAC4–RUNX2–GAMT-mediated apoptosis. Molecular Cancer, 23(1), 27.

Liu, Y., Jiang, B., Lin, C., Zhu, W., Chen, D., Sheng, Y., ... & Wu, M. (2023). m7G-related gene NUDT4 as a novel biomarker promoting cancer cell proliferation in lung adenocarcinoma. Frontiers in Oncology, 12, 1055605.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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