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Mouse Anti-NUDT4 Recombinant Antibody (2F2) (CBMAB-N3907-WJ)

This product is a Mouse antibody that recognizes NUDT4. The antibody 2F2 can be used for immunoassay techniques such as: ELISA, WB.
See all NUDT4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F2
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 4
Introduction
The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq, Jul 2008]
Entrez Gene ID
11163
UniProt ID
Q9NZJ9
Alternative Names
Nudix Hydrolase 4; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4; Diphosphoinositol Polyphosphate Phosphohydrolase Type 2; Diadenosine 5,5-P1,P6-Hexaphosphate Hydrolase 2; DIPP-2; DIPP2; Diphosphoinositol Polyphosphate Phosphohydrolase 2; Nucleoside Diphosphate-Linked Moiety X Motif 4;
Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170).
Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170).
Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).
Biological Process
Adenosine 5'-(hexahydrogen pentaphosphate) catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Calcium-mediated signalingManual Assertion Based On ExperimentTAS:UniProtKB
Cyclic-nucleotide-mediated signalingManual Assertion Based On ExperimentTAS:UniProtKB
Diadenosine hexaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine pentaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diphosphoinositol polyphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transduction1 PublicationNAS:UniProtKB
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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