NUDT4

The protein encoded by this gene regulates the turnover of diphosphoinositol polyphosphates. The turnover of these high-energy diphosphoinositol polyphosphates represents a molecular switching activity with important regulatory consequences. Molecular switching by diphosphoinositol polyphosphates may contribute to regulating intracellular trafficking. Several alternatively spliced transcript variants have been described, but the full-length nature of some variants has not been determined. Isoforms DIPP2alpha and DIPP2beta are distinguishable from each other solely by DIPP2beta possessing one additional amino acid due to intron boundary skidding in alternate splicing. [provided by RefSeq]

Full Name

nudix (nucleoside diphosphate linked moiety X)-type motif 4

Function

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:10777568, PubMed:12370170).
Can also catalyze the hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) but not diadenosine 5',5'''-P1,P5-pentaphosphate (Ap5A) and the major reaction products are ADP and p4a from Ap6A (PubMed:12370170).
Also able to hydrolyze 5-phosphoribose 1-diphosphate (PubMed:12370170).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).

Biological Process

Adenosine 5'-(hexahydrogen pentaphosphate) catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Calcium-mediated signalingManual Assertion Based On ExperimentTAS:UniProtKB
Cyclic-nucleotide-mediated signalingManual Assertion Based On ExperimentTAS:UniProtKB
Diadenosine hexaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diadenosine pentaphosphate catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Diphosphoinositol polyphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Intracellular signal transduction1 PublicationNAS:UniProtKB

Cellular Location

Cytoplasm