Mouse Anti-NUDT7 Recombinant Antibody (D-1) (CBMAB-N3924-WJ)

This product is a Mouse antibody that recognizes NUDT7. The antibody D-1 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NUDT7 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

D-1

Application

WB, IP, IF, ELISA

Basic Information

Specificity

Human

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Nudix Hydrolase 7

Introduction

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Entrez Gene ID

283927

UniProt ID

P0C024

Alternative Names

Nudix Hydrolase 7; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 7; Nucleoside Diphosphate-Linked Moiety X Motif 7; Nudix Motif 7; EC 3.6.1.-;

Function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity).
Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity).
Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity).
Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity).
May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).
Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).

Biological Process

Acetyl-CoA catabolic processISS:UniProtKB
Brown fat cell differentiationIEA:Ensembl
Butyryl-CoA catabolic processISS:UniProtKB
Coenzyme A catabolic processISS:UniProtKB
Malonyl-CoA catabolic processISS:UniProtKB
Medium-chain fatty-acyl-CoA catabolic processISS:UniProtKB
Nucleoside diphosphate metabolic processIEA:InterPro
Propionyl-CoA catabolic processISS:UniProtKB
Propionyl-CoA metabolic processISS:UniProtKB
Succinyl-CoA catabolic processISS:UniProtKB

Cellular Location

Peroxisome

References

Bhandari, S., Hong, K., Miyawaki-Kuwakado, A., Tomimatsu, K., Kim, Y. I., Nam, I. K., ... & Choe, S. K. (2023). nudt7 gene depletion causes transcriptomic change in early development of zebrafish. The Journal of Biochemistry, 173(1), 53-63.

Vickers, S. D., Shumar, S. A., Saporito, D. C., Kunovac, A., Hathaway, Q. A., Mintmier, B., ... & Leonardi, R. (2023). NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet. Journal of Biological Chemistry, 299(1).

Song, J., Kim, E. H., Yang, J. H., Kim, D., Robby, A. I., Kim, S. A., ... & Jin, E. J. (2023). Upregulated FOXM1 stimulates chondrocyte senescence in Acot12-/-Nudt7-/-double knockout mice. Theranostics, 13(15), 5207.

Song, J., Baek, I. J., Park, S., Oh, J., Kim, D., Song, K., ... & Jin, E. J. (2022). Deficiency of peroxisomal NUDT7 stimulates de novo lipogenesis in hepatocytes. Iscience, 25(10).

Song, J., Park, S., Oh, J., Kim, D., Ryu, J. H., Park, W. C., ... & Jin, E. J. (2020). NUDT7 loss promotes KrasG12D CRC development. Cancers, 12(3), 576.

Shumar, S. A., Kerr, E. W., Fagone, P., Infante, A. M., & Leonardi, R. (2019). Overexpression of Nudt7 decreases bile acid levels and peroxisomal fatty acid oxidation in the liver. Journal of lipid research, 60(5), 1005-1019.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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