NUDT7

The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Full Name

Nudix Hydrolase 7

Function

Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity).
Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity).
Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity).
Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity).
May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity).
Does not play a role in U8 snoRNA decapping activity (By similarity).
Binds U8 snoRNA (By similarity).
Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).

Biological Process

Acetyl-CoA catabolic processISS:UniProtKB
Brown fat cell differentiationIEA:Ensembl
Butyryl-CoA catabolic processISS:UniProtKB
Coenzyme A catabolic processISS:UniProtKB
Malonyl-CoA catabolic processISS:UniProtKB
Medium-chain fatty-acyl-CoA catabolic processISS:UniProtKB
Nucleoside diphosphate metabolic processIEA:InterPro
Propionyl-CoA catabolic processISS:UniProtKB
Propionyl-CoA metabolic processISS:UniProtKB
Succinyl-CoA catabolic processISS:UniProtKB

Cellular Location

Peroxisome