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Mouse Anti-NUP85 Recombinant Antibody (CBWJN-1626) (CBMAB-N4022-WJ)

This product is a Mouse antibody that recognizes NUP85. The antibody CBWJN-1626 can be used for immunoassay techniques such as: WB.
See all NUP85 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-1626
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
nucleoporin 85kDa
Introduction
This gene encodes a protein component of the Nup107-160 subunit of the nuclear pore complex. Nuclear pore complexes are embedded in the nuclear envelope and promote bidirectional transport of macromolecules between the cytoplasm and nucleus. The encoded protein can also bind to the C-terminus of chemokine (C-C motif) receptor 2 (CCR2) and promote chemotaxis of monocytes, thereby participating in the inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Entrez Gene ID
Human79902
Mouse445007
Rat287830
UniProt ID
HumanQ9BW27
MouseQ8R480
RatQ4QQS8
Alternative Names
Nucleoporin 85; Nucleoporin 85kDa; Nucleoporin Nup75; Nucleoporin Nup85; FROUNT; Nup75;
Function
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872).
As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872).
The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356).
NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708).
Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708).
Involved in nephrogenesis (PubMed:30179222).
Biological Process
Lamellipodium assemblyIEA:Ensembl
Macrophage chemotaxisIEA:Ensembl
mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Nephron developmentManual Assertion Based On ExperimentIMP:UniProtKB
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nuclear pore complex
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Cytoplasm
Nucleus membrane
During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356).
Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708).
Involvement in disease
Nephrotic syndrome 17 (NPHS17):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form that progresses to end-stage renal failure. NPHS17 is an autosomal recessive, steroid-resistant progressive form with onset in the first decade of life.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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