NUP85

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP85 is part of one such subcomplex, Nup107-160. [provided by RefSeq]

Full Name

nucleoporin 85kDa

Function

Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (PubMed:12718872).
As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus (PubMed:12718872).
The Nup107-160 complex seems to be required for spindle assembly during mitosis (PubMed:16807356).
NUP85 is required for membrane clustering of CCL2-activated CCR2 (PubMed:15995708).
Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade (PubMed:15995708).
Involved in nephrogenesis (PubMed:30179222).

Biological Process

Lamellipodium assemblyIEA:Ensembl
Macrophage chemotaxisIEA:Ensembl
mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Nephron developmentManual Assertion Based On ExperimentIMP:UniProtKB
Nucleocytoplasmic transport1 PublicationIC:ComplexPortal
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus, nuclear pore complex
Chromosome, centromere, kinetochore
Cytoplasm, cytoskeleton, spindle
Cytoplasm
Nucleus membrane
During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356).
Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708).

Involvement in disease

Nephrotic syndrome 17 (NPHS17):
A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form that progresses to end-stage renal failure. NPHS17 is an autosomal recessive, steroid-resistant progressive form with onset in the first decade of life.