Mouse Anti-NXT1 Recombinant Antibody (4F11) (CBMAB-N4072-WJ)

Name: Mouse Anti-NXT1 Recombinant Antibody (4F11)
SKU: CBMAB-N4072-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4F11

Application

ELISA, WB

Specificity

Human

Antibody Isotype

IgG1, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

NTF2-like export factor 1

Introduction

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

29107

UniProt ID

Q9UKK6

Alternative Names

Nuclear Transport Factor 2 Like Export Factor 1; NTF2-Like Export Factor 1; NTX2-Like Export Factor1; Protein P15; Nuclear Transport Factor 2-Like Export Factor 1; NTF2-Related Export Protein 1; NUTF-Like Export Factor 1; MTr2; P15;

Function

Stimulator of protein export for NES-containing proteins (PubMed:10567585).
Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583).
The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).

Biological Process

mRNA export from nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Nucleocytoplasmic transportManual Assertion Based On ExperimentIBA:GO_Central
Protein export from nucleusIEA:Ensembl
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Nucleus speckle
Cytoplasm
Shuttles between the nucleus and the cytoplasm.

Hu, J., Wang, H., He, D., Yang, R., Yang, D., Li, D., ... & Li, Y. (2022). Genetic characterization of nuclear export factor NXT1 and its paralog NXT2 in primates and murine rodents. Zoology, 151, 126002.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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