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Mouse Anti-NXT1 Recombinant Antibody (4F11) (CBMAB-N4072-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4F11
Antibody Isotype
IgG1, λ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, λ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NTF2-like export factor 1
Introduction
The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
29107
UniProt ID
Q9UKK6
Alternative Names
Nuclear Transport Factor 2 Like Export Factor 1; NTF2-Like Export Factor 1; NTX2-Like Export Factor1; Protein P15; Nuclear Transport Factor 2-Like Export Factor 1; NTF2-Related Export Protein 1; NUTF-Like Export Factor 1; MTr2; P15;
Function
Stimulator of protein export for NES-containing proteins (PubMed:10567585).
Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583).
The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).
Biological Process
mRNA export from nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Nucleocytoplasmic transportManual Assertion Based On ExperimentIBA:GO_Central
Protein export from nucleusIEA:Ensembl
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus speckle
Cytoplasm
Shuttles between the nucleus and the cytoplasm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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