NXT1

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq]

Full Name

NTF2-like export factor 1

Function

Stimulator of protein export for NES-containing proteins (PubMed:10567585).
Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583).
The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:19165146, PubMed:11259602).

Biological Process

mRNA export from nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Nucleocytoplasmic transportManual Assertion Based On ExperimentIBA:GO_Central
Protein export from nucleusIEA:Ensembl
Protein import into nucleusManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Nucleus speckle
Cytoplasm
Shuttles between the nucleus and the cytoplasm.