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Mouse Anti-OAS3 Recombinant Antibody (CBXO-0325) (CBMAB-O0211-CQ)

This product is a mouse antibody that recognizes OAS3. The antibody CBXO-0325 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all OAS3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBXO-0325
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
2'-5'-Oligoadenylate Synthetase 3
Introduction
This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
Entrez Gene ID
Mouse246727
Rat494202
UniProt ID
MouseQ8VI93
RatQ5MYT7
Alternative Names
2'-5'-Oligoadenylate Synthetase 3; 2-5-Oligoadenylate Synthetase 3; 2-5-Oligoadenylate Synthetase 3, 100kDa; (2-5)Oligo(A) Synthase 3; 2-5A Synthase 3; P100 OAS; P100OAS; 2-5-Oligoadenylate Synthetase 3 (100 KD)
Function
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Biological Process
Defense response to bacteriumManual Assertion Based On ExperimentIMP:ARUK-UCL
Defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Innate immune responseIEA:UniProtKB-KW
MDA-5 signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine (C-C motif) ligand 5 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine (C-X-C motif) ligand 2 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of chemokine (C-X-C motif) ligand 9 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of IP-10 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of type I interferon-mediated signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Negative regulation of viral genome replicationManual Assertion Based On ExperimentIDA:UniProtKB
Nucleobase-containing compound metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interferon-beta productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of monocyte chemotactic protein-1 productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Regulation of ribonuclease activityManual Assertion Based On ExperimentIDA:UniProtKB
Response to virusManual Assertion Based On ExperimentIDA:UniProtKB
RIG-I signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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