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Mouse Anti-ODAM Recombinant Antibody (2F8) (CBMAB-O0301-CQ)

This product is a mouse antibody that recognizes ODAM. The antibody 2F8 can be used for immunoassay techniques such as: ELISA, WB.
See all ODAM antibodies
Published Data
Fig. 1 Total protein extracts obtanied from DeCy-1 cells, a solid/multicystic ameloblastoma (SMA) (positive control), and MDAMB231 cells (negative control) were resolved by SDS-PAGE and submitted to Western blot assays using the anti-ODAM antibody.
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Fig. 2 DeCy-1 cells were fixed, permeabilized and incubated with the anti-ODAM antibody, and then, with a secondary antibody coupled to Alexa 488 (green).
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F8
Antibody Isotype
IgG2a, Κ
Application
ELISA, WB

Basic Information

Immunogen
ODAM (AAH17796.1, 1 a.a.-153 a.a) full-length Recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, Κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
odontogenic, ameloblast asssociated
Introduction
ODAM (Odontogenic, Ameloblast Associated) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Metabolism of proteins.
Entrez Gene ID
54959
UniProt ID
A1E959
Alternative Names
Odontogenic, Ameloblast Associated; APIN; Odontogenic Ameloblast-Associated Protein; Odontogenic, Ameloblast Asssociated
Function
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.
Biological Process
Biomineral tissue developmentIEA:UniProtKB-KW
Inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Odontogenesis of dentin-containing toothManual Assertion Based On ExperimentIEP:HGNC-UCL
Positive regulation of epithelial cell proliferation involved in wound healingManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted
Cytoplasm
Nucleus
PTM
O-glycosylated.

Al‐Qazzaz, H. H., Abdullah, B. H., & Museedi, O. S. (2023). Correlation of amyloid and ameloblast‐associated proteins to odontogenic cysts and tumors: A cross‐sectional study. Health Science Reports, 6(1), e1061.

Hou, M., Liu, S., Yan, K., Sun, Z., & Li, S. (2023). Downregulation of odontogenic ameloblast-associated protein in the progression of periodontal disease affects cell adhesion, proliferation, and migration. Archives of Oral Biology, 145, 105588.

Yamaguchi, K., Horie, C., Takane, K., Ikenoue, T., Nakagawa, S., Isobe, Y., ... & Furukawa, Y. (2023). Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β‐catenin signaling pathway. Cancer Science, 114(3), 948-960.

Zhu, S., Xiang, C., Charlesworth, O., Bennett, S., & Xu, J. (2022). The versatile roles of odontogenic ameloblast-associated protein in odontogenesis, junctional epithelium regeneration and periodontal disease. Frontiers in Physiology, 13, 1003931.

Tsuruya, Y., Yamaguchi, A., Yamazaki-Takai, M., Mezawa, M., Takai, H., Nakayama, Y., & Ogata, Y. (2022). Transcriptional regulation of human odontogenic ameloblast-associated protein gene by tumor necrosis factor-α. Inflammation Research, 71(1), 119-129.

Tsuruya, Y., Yamaguchi, A., Yamazaki-Takai, M., Zhenyu, J., Takai, H., Nakayama, Y., & Ogata, Y. (2022). Interleukin-1β regulates odontogenic ameloblast-associated protein gene transcription in human gingival epithelial cells. Odontology, 110(3), 557-568.

Song, D., Yang, S., Tan, T., Wang, R., Ma, Z., Wang, Y., & Wang, L. (2021). ODAM promotes junctional epithelium‐related gene expression via activation of WNT1 signaling pathway in an ameloblast‐like cell line ALC. Journal of Periodontal Research, 56(3), 482-491.

Koutlas, I. G., Ponce, K. J., Wazen, R. M., & Nanci, A. (2021). An unusual maxillary tumor with tubuloductal epithelial structures, solid epithelial nests and stromal odontogenic ameloblast-associated protein deposits. Tubuloductal/syringoid variant of central odontogenic fibroma with amyloid?. Head and Neck Pathology, 1-9.

Springer, M. S., Emerling, C. A., Gatesy, J., Randall, J., Collin, M. A., Hecker, N., ... & Delsuc, F. (2019). Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales. BMC evolutionary biology, 19, 1-19.

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For research use only. Not intended for any clinical use.

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