ODAM

ODAM (Odontogenic, Ameloblast Associated) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Metabolism of proteins.

Full Name

odontogenic, ameloblast asssociated

Function

Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface.

Biological Process

Biomineral tissue developmentIEA:UniProtKB-KW
Inflammatory responseManual Assertion Based On ExperimentIDA:UniProtKB
Odontogenesis of dentin-containing toothManual Assertion Based On ExperimentIEP:HGNC-UCL
Positive regulation of epithelial cell proliferation involved in wound healingManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of protein phosphorylationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Cytoplasm
Nucleus

PTM

O-glycosylated.