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Mouse Anti-OGFOD1 Recombinant Antibody (1F4) (CBMAB-O0325-CQ)

This product is a mouse antibody that recognizes OGFOD1. The antibody 1F4 can be used for immunoassay techniques such as: FC, IHC-P, WB.
See all OGFOD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1F4
Antibody Isotype
IgG1
Application
FC, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% Sodium Azide
Concentration
0.41 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1
Introduction
OGFOD1 (2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
Entrez Gene ID
55239
UniProt ID
Q8N543
Alternative Names
2-Oxoglutarate And Iron Dependent Oxygenase Domain Containing 1; 2-Oxoglutarate And Iron-Dependent Oxygenase Domain-Containing Protein 1; Termination And Polyadenylation 1 Homolog; US12 Prolyl 3-Hydroxylase; TPA1; TPA1, Termination And Polyadenylation 1, Homolog (S. Cerevisiae); 2-Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 1
Function
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Peptidyl-proline hydroxylationManual Assertion Based On ExperimentIDA:CACAO
Protein hydroxylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translational terminationManual Assertion Based On ExperimentIMP:UniProtKB
Stress granule assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Isoform 1
Cytoplasm
Nucleus
Mainly nuclear. A portion relocalizes to cytoplasmic stress granules upon stress.
Isoform 2
Cytoplasm

Xie, J., Zhang, Y., Li, B., Xi, W., Wang, Y., Li, L., ... & Zhang, Z. (2024). Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke. Journal of Translational Medicine, 22(1), 1-27.

Fujisaki, T., Saito, K., Kikuchi, T., & Kondo, E. (2023). The prolyl hydroxylase OGFOD1 promotes cancer cell proliferation by regulating the expression of cell cycle regulators. FEBS letters, 597(8), 1073-1085.

Rodriguez, R., Harris, M., Murphy, E., & Kennedy, L. M. (2023). OGFOD1 modulates the transcriptional and proteomic landscapes to alter isoproterenol-induced hypertrophy susceptibility. Journal of Molecular and Cellular Cardiology, 179, 42-46.

Harris, M., Sun, J., Keeran, K., Aponte, A., Singh, K., Springer, D., ... & Kennedy, L. M. (2022). Ogfod1 deletion increases cardiac beta-alanine levels and protects mice against ischaemia–reperfusion injury. Cardiovascular Research, 118(13), 2847-2858.

Lee, H. T., Lee, I. H., Kim, J. H., Lee, S., Kwak, S., Suh, M. Y., ... & Youn, H. D. (2021). Phosphorylation of OGFOD1 by cell cycle-dependent kinase 7/9 enhances the transcriptional activity of RNA polymerase II in breast cancer cells. Cancers, 13(14), 3418.

Kennedy, L., Sun, J., Harris, M., Cockman, M., Ratcliffe, P., & Murphy, E. (2020). Abstract MP121: Deleting the 2-oxoglutarate-and Iron-dependent Prolyl Hydroxylase Ogfod1 Alters Purine Nucleotide Regulation and is Cardioprotective. Circulation Research, 127(Suppl_1), AMP121-AMP121.

Yin, D., Wang, Q., Wang, S., Zhu, G., Tang, Q., & Liu, J. (2020). OGFOD1 negatively regulated by miR-1224-5p promotes proliferation in human papillomavirus-infected laryngeal papillomas. Molecular Genetics and Genomics, 295, 675-684.

Harris, M., Kennedy, L., Sun, J., Cockman, M., Ratcliffe, P., & Murphy, E. (2020). Endoplasmic Reticulum Stress Alters the Localization of the Prolyl Hydroxylase Ogfod1 in Adult Mouse Cardiomyocytes. Circulation Research, 127(Suppl_1), A317-A317.

Thinnes, C. C., Lohans, C. T., Abboud, M. I., Yeh, T. L., Tumber, A., Nowak, R. P., ... & Schofield, C. J. (2019). Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding. Chemistry–A European Journal, 25(8), 2019-2024.

Stoehr, A., Kennedy, L., Yang, Y., Patel, S., Lin, Y., Linask, K. L., ... & Murphy, E. (2019). The ribosomal prolyl-hydroxylase OGFOD1 decreases during cardiac differentiation and modulates translation and splicing. JCI insight, 4(13).

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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