Sign in or Register   Sign in or Register
  |  

Mouse Anti-OGN (AA 200-298) Recombinant Antibody (CBFYM-3038) (CBMAB-M3234-FY)

This product is mouse antibody that recognizes OGN. The antibody CBFYM-3038 can be used for immunoassay techniques such as: ELISA.
See all OGN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3038
Antibody Isotype
IgG2a, k
Application
ELISA

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 200-298

Target

Full Name
osteoglycin
Introduction
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
4969
UniProt ID
P20774
Alternative Names
Osteoglycin; Osteoinductive Factor; Mimecan Proteoglycan; SLRR3A; OIF; Corneal Keratan Sulfate Proteoglycan; Osteoglycin (Osteoinductive Factor); Mimecan; OG
Function
Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
Biological Process
Negative regulation of smooth muscle cell proliferationISS:UniProtKB
Cellular Location
Secreted, extracellular space, extracellular matrix
PTM
N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.

Dings, M. P., Manoukian, P., Waasdorp, C., Quik, J. S., Strijker, M., Lodestijn, S. C., ... & Bijlsma, M. F. (2023). Serum levels of iCAF‐derived osteoglycin predict favorable outcome in pancreatic cancer. International Journal of Cancer, 152(3), 511-523.

Qian, C., Zhao, C., Gao, Q., Gu, J., Han, W., Jiang, H., ... & Tu, H. (2022). Reduced Osteoglycin Protein Expression Correlates with Lymph Node Metastasis and Low Differentiation in Human Gastric Cancer.

Qin, W., Zhang, J., Rong, R., Zhang, L., Gao, H., Liu, C., ... & Zhang, Y. (2022). Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4. Tissue and Cell, 78, 101867.

Nulali, J., Zhan, M., Zhang, K., Tu, P., Liu, Y., & Song, H. (2022). Osteoglycin: an ECM factor regulating fibrosis and tumorigenesis. Biomolecules, 12(11), 1674.

Woessner, M. N., Hiam, D., Smith, C., Lin, X., Zarekookandeh, N., Tacey, A., ... & Levinger, I. (2022). Osteoglycin across the adult lifespan. The Journal of Clinical Endocrinology & Metabolism, 107(4), e1426-e1433.

Zuo, Z., Li, M. H., Zheng, X. H., Yao, W. M., Wang, H., & Li, X. L. (2022). Elevated plasma levels of osteoglycin in cardiovascular patients: A systematic review and meta-analysis. Annals of Palliative Medicine, 11(2), 49805-49505.

Wang, Z., Zhuang, X., Chen, B., & Wei, M. (2021). Osteoglycin knockdown promotes vascular smooth muscle cell proliferation and migration in aortic dissection via the VEGF/VEGFR2 axis. Molecular Medicine Reports, 23(1), 1-1.

González-Salvatierra, S., García-Fontana, C., Andújar-Vera, F., Grau-Perales, A. B., Martínez-Heredia, L., Avilés-Pérez, M. D., ... & García-Fontana, B. (2021). Osteoglycin as a potential biomarker of mild kidney function impairment in type 2 diabetes patients. Journal of Clinical Medicine, 10(10), 2209.

Xu, T., Zhang, R., Dong, M., Zhang, Z., Li, H., Zhan, C., & Li, X. (2019). Osteoglycin (OGN) inhibits cell proliferation and invasiveness in breast cancer via PI3K/Akt/mTOR signaling pathway. OncoTargets and therapy, 10639-10650.

Starup-Linde, J., Viggers, R., & Handberg, A. (2019). Osteoglycin and Bone—a Systematic Review. Current osteoporosis reports, 17, 250-255.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-OGN (AA 200-298) Recombinant Antibody (CBFYM-3038)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare