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Mouse Anti-OIP5 Recombinant Antibody (CBXO-0043) (CBMAB-O0344-CQ)

This product is a mouse antibody that recognizes OIP5. The antibody CBXO-0043 can be used for immunoassay techniques such as: WB.
See all OIP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0043
Antibody Isotype
IgG2a
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Opa interacting protein 5
Introduction
The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
11339
UniProt ID
O43482
Alternative Names
Opa Interacting Protein 5; Cancer/Testis Antigen 86; Opa-Interacting Protein 5; MIS18B; CT86; MIS18 Kinetochore Protein Homolog B (S. Pombe); MIS18 Kinetochore Protein Homolog B; LAP2alpha Interactor-25
Function
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Biological Process
Cell communication1 PublicationNAS:UniProtKB
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
CENP-A containing chromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Hiura, K., Watanabe, M., Hirose, N., Nakano, K., Okamura, T., Sasaki, H., & Sasaki, N. (2024). Mitotic Spindle Positioning (MISP) Facilitates Colorectal Cancer Progression by Forming a Complex with Opa Interacting Protein 5 (OIP5) and Activating the JAK2-STAT3 Signaling Pathway. International Journal of Molecular Sciences, 25(5), 3061.

Zhu, M., Takano, A., Tsevegjav, B., Yoshitake, Y., Shinohara, M., & Daigo, Y. (2022). Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer. International Journal of Oncology, 60(3), 1-11.

Shi, C., Zhang, H., Wang, M., Tian, R., Li, X., Feng, Y., ... & Qin, R. (2022). OPA interacting protein 5 antisense RNA 1 expedites cell migration and invasion through FOXM1/Wnt/β-catenin pathway in pancreatic cancer. Digestive Diseases and Sciences, 1-10.

Zhang, L., Cai, Y., Tian, C., Li, Y., Ma, K., Gao, X., ... & Ma, Z. (2022). LncRNA Opa interacting protein 5‐antisense RNA 1 (OIP5‐AS1) promotes the migration, invasion and epithelial‐mesenchymal transition (EMT) through targeting miR‐147a/insulin‐like growth factor 1 receptor (IGF1R) pathway in cervical cancer tissues and cell model. Journal of Obstetrics and Gynaecology Research, 48(5), 1222-1232.

Chen, L., Wang, R., Gao, L., & Shi, W. (2020). Opa-interacting protein 5 expression in human glioma tissues is essential to the biological function of u251 human malignant glioma cells. Cancer Control, 27(1), 1073274820968914.

Liang, J., Tian, X. F., & Yang, W. (2020). Effects of long non-coding RNA Opa-interacting protein 5 antisense RNA 1 on colon cancer cell resistance to oxaliplatin and its regulation of microRNA-137. World Journal of Gastroenterology, 26(13), 1474.

Yang, J., Jiang, B., Hai, J., Duan, S., Dong, X., & Chen, C. (2019). Long noncoding RNA opa‐interacting protein 5 antisense transcript 1 promotes proliferation and invasion through elevating integrin α6 expression by sponging miR‐143‐3p in cervical cancer. Journal of cellular biochemistry, 120(1), 907-916.

Li, Y., Xiao, F., Li, W., Hu, P., Xu, R., Li, J., ... & Zhu, C. (2019). Overexpression of Opa interacting protein 5 increases the progression of liver cancer via BMPR2/JUN/CHEK1/RAC1 dysregulation. Oncology Reports, 41(4), 2075-2088.

Chen, X., Xiong, D., Yang, H., Ye, L., Mei, S., Wu, J., ... & Huang, L. (2019). Long noncoding RNA OPA‐interacting protein 5 antisense transcript 1 upregulated SMAD3 expression to contribute to metastasis of cervical cancer by sponging miR‐143‐3p. Journal of cellular physiology, 234(4), 5264-5275.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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