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OIP5

The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene.
Full Name
Opa interacting protein 5
Function
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.
Biological Process
Cell communication1 PublicationNAS:UniProtKB
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
CENP-A containing chromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
Chromosome, centromere
Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
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Anti-OIP5 antibodies

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Mouse Anti-OIP5 Recombinant Antibody (3G10-1D5) (CBMAB-A6213-LY)

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Target: OIP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3G10-1D5
Application*: WB, E
Datasheet SDS

Mouse Anti-OIP5 Recombinant Antibody (CBXO-0404) (CBMAB-O0457-CQ)

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Target: OIP5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXO-0404
Application*: E, WB
Datasheet SDS

Mouse Anti-OIP5 (AA 1-230) Recombinant Antibody (CBXO-0452) (CBMAB-O0345-CQ)

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Target: OIP5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXO-0452
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-OIP5 Recombinant Antibody (CBXO-0043) (CBMAB-O0344-CQ)

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Target: OIP5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0043
Application*: WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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