OIP5

The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene.

Full Name

Opa interacting protein 5

Function

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Biological Process

Cell communication1 PublicationNAS:UniProtKB
Cell cycleIEA:UniProtKB-KW
Cell divisionIEA:UniProtKB-KW
CENP-A containing chromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Chromosome segregationManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Chromosome
Chromosome, centromere
Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.

Anti-OIP5 antibodies

Mouse Anti-OIP5 Recombinant Antibody (CBXO-0404) (CBMAB-O0457-CQ)

Datasheet

SDS

Target: OIP5

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXO-0404

Application*: E, WB

Mouse Anti-OIP5 (AA 1-230) Recombinant Antibody (CBXO-0452) (CBMAB-O0345-CQ)

Datasheet

SDS

Target: OIP5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXO-0452

Application*: E, IP, WB

Mouse Anti-OIP5 Recombinant Antibody (CBXO-0043) (CBMAB-O0344-CQ)

Datasheet

SDS

Target: OIP5

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXO-0043

Application*: WB

Mouse Anti-OIP5 Recombinant Antibody (3G10-1D5) (CBMAB-A6213-LY)

Datasheet

SDS

Target: OIP5

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3G10-1D5

Application*: WB, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)