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Mouse Anti-OLIG1 Recombinant Antibody (CBXO-0046) (CBMAB-O0367-CQ)

This product is a mouse antibody that recognizes OLIG1. The antibody CBXO-0046 can be used for immunoassay techniques such as: ELISA, IHC, WB.
See all OLIG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0046
Antibody Isotype
IgG2b
Application
ELISA, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, 5% trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
oligodendrocyte transcription factor 1
Introduction
OLIG1 (Oligodendrocyte Transcription Factor 1) is a Protein Coding gene. Diseases associated with OLIG1 include Oligodendroglioma. Among its related pathways are Neural Crest Differentiation and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include protein dimerization activity. An important paralog of this gene is OLIG2.
Entrez Gene ID
116448
UniProt ID
Q8TAK6
Alternative Names
Oligodendrocyte Transcription Factor 1; Oligodendrocyte-Specific BHLH Transcription Factor 1; Basic Domain, Helix-Loop-Helix Protein, Class B, 6; Oligodendrocyte Lineage Transcription Factor 1; Class E Basic Helix-Loop-Helix Protein 21; Class B Basic Helix-Loop-Helix Protein 6; BHLHE21; Oligo1; BHLHB6
Function
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube (By similarity).
Biological Process
Neuron differentiationManual Assertion Based On ExperimentIBA:GO_Central
Neuron fate commitmentIEA:Ensembl
Oligodendrocyte developmentIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Verma, R., Chen, X., Xin, D., Luo, Z., Ogurek, S., Xin, M., ... & Lu, Q. R. (2023). Olig1/2-Expressing Intermediate Lineage Progenitors Are Predisposed to PTEN/p53-Loss–Induced Gliomagenesis and Harbor Specific Therapeutic Vulnerabilities. Cancer Research, 83(6), 890-905.

Zhao, H., Gao, X. Y., Wu, X. J., Zhang, Y. B., & Wang, X. F. (2022). The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats. Neurological Research, 44(4), 318-330.

Mashayekhi, F., Shabani, S., Talesh Sasani, S., & Salehi, Z. (2021). The enhancing effect of electromagnetic field on the expression of Oligodendrocyte transcription factor 1 and 2 (Olig1/2) in the mice cerebral cortex. Nova Biologica Reperta, 7(4), 374-380.

Joshi, M., Shah, D. P., & Krishnakumar, A. (2021). Extreme glycemic fluctuations debilitate NRG1, ErbB receptors and Olig1 function: association with regeneration, cognition and mood alterations during diabetes. Molecular Neurobiology, 58(9), 4727-4744.

Wang, X., Su, Y., Li, T., Yu, G., Wang, Y., Chen, X., ... & Niu, J. (2021). Quetiapine promotes oligodendroglial process outgrowth and membrane expansion by orchestrating the effects of Olig1. Glia, 69(7), 1709-1722.

Panagopoulos, I., Gorunova, L., Johannsdottir, I. M. R., Andersen, K., Holth, A., Beiske, K., & Heim, S. (2020). Chromosome Translocation t (14; 21)(q11; q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis. Cancer Genomics & Proteomics, 17(1), 41-48.

Zhao, H., Gao, X. Y., Liu, Z. H., Lin, J. W., Wang, S. P., Wang, D. X., & Zhang, Y. B. (2019). Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats. Molecular Medicine Reports, 20(5), 4603-4611.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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