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Mouse Anti-ONECUT2 (AA 185-326) Recombinant Antibody (CBXO-0389) (CBMAB-O0453-CQ)

This product is a mouse antibody that recognizes ONECUT2 (AA 185-326). The antibody CBXO-0389 can be used for immunoassay techniques such as: WB, ICC.
See all ONECUT2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0389
Antibody Isotype
IgG2b
Application
WB, ICC

Basic Information

Immunogen
E. coli-derived recombinant human ONECUT2/OC-2, Gln185-Thr326, Accession # O95948
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 185-326

Target

Full Name
ONECUT2
Introduction
This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation.
Entrez Gene ID
9480
UniProt ID
O95948
Alternative Names
One Cut Homeobox 2; Hepatocyte Nuclear Factor 6-Beta; Transcription Factor ONECUT-2; HNF-6-Beta; OC-2; ONECUT-2 Homeodomain Transcription Factor
Function
Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B.
Biological Process
Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Cell fate commitmentIEA:Ensembl
Cilium assemblyIEA:Ensembl
Endocrine pancreas developmentIEA:Ensembl
Epithelial cell developmentIEA:Ensembl
Liver developmentIEA:Ensembl
Negative regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Peripheral nervous system neuron developmentIEA:Ensembl
Positive regulation of cell migrationIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Regulation of cell-matrix adhesionIEA:Ensembl
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus

Haddadi, R., Gazzaz, N., Aloraidi, A., Aldahmash, B., Almuhaini, G., Alrfaei, B. M., & Alshehri, M. (2024). ONECUT2 regulates proliferation and apoptosis in glioblastoma cell lines. Journal of King Saud University-Science, 36(2), 103057.

Yi, Y., Yang, N., Yang, Z., Tao, X., & Li, Y. (2022). LncRNA TM1‐3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR‐144‐3p/ONECUT2 Axis. Orthopaedic Surgery, 14(11), 3078-3091.

Liu, D., Zhang, T., Chen, X., Zhang, B., Wang, Y., Xie, M., ... & Xia, L. (2021). ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY. Cell Death & Disease, 12(12), 1113.

Jiang, Z., Tai, Q., Xie, X., Hou, Z., Liu, W., Yu, Z., ... & Chen, S. (2021). EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway. Journal of Experimental & Clinical Cancer Research, 40, 1-15.

Yu, J., Li, D., & Jiang, H. (2020). Emerging role of ONECUT2 in tumors. Oncology Letters, 20(6), 1-1.

Chen, J., Chen, J., Sun, B., Wu, J., & Du, C. (2020). ONECUT2 accelerates tumor proliferation through activating ROCK1 expression in gastric cancer. Cancer Management and Research, 6113-6121.

Seo, E. H., Kim, H. J., Kim, J. H., Lim, B., Park, J. L., Kim, S. Y., ... & Kim, Y. S. (2020). ONECUT2 upregulation is associated with CpG hypomethylation at promoter‐proximal DNA in gastric cancer and triggers ACSL5. International Journal of Cancer, 146(12), 3354-3368.

Guo, H., Ci, X., Ahmed, M., Hua, J. T., Soares, F., Lin, D., ... & He, H. H. (2019). ONECUT2 is a driver of neuroendocrine prostate cancer. Nature communications, 10(1), 278.

Ma, Q., Wu, K., Li, H., Li, H., Zhu, Y., Hu, G., ... & Kong, X. (2019). ONECUT2 overexpression promotes RAS-driven lung adenocarcinoma progression. Scientific reports, 9(1), 20021.

Shen, M., Dong, C., Ruan, X., Yan, W., Cao, M., Pizzo, D., ... & Wang, S. E. (2019). Chemotherapy-induced extracellular vesicle miRNAs promote breast cancer stemness by targeting ONECUT2. Cancer research, 79(14), 3608-3621.

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For research use only. Not intended for any clinical use.

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