Mouse Anti-OPCML (AA 28-322) Recombinant Antibody (CBXO-0381) (CBMAB-O0227-CQ)

Name: Mouse Anti-OPCML (AA 28-322) Recombinant Antibody (CBXO-0381)
SKU: CBMAB-O0227-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0381

Application

Immunogen

Recombinant human OBCAM, Gly28-Asn322, Accession # Q14982

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS with Trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 28-322

More Infomation

Target

Full Name

Opioid Binding Protein/Cell Adhesion Molecule Like

Introduction

This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Entrez Gene ID

4978

UniProt ID

Q14982

Alternative Names

Opioid Binding Protein/Cell Adhesion Molecule Like; IgLON Family Member 1; IGLON1; OBCAM; Opioid Binding Protein/Cell Adhesion Molecule-Like Preprotein; Opioid-Binding Protein/Cell Adhesion Molecule; Opioid-Binding Cell Adhesion Molecule; OPCM

Function

Binds opioids in the presence of acidic lipids; probably involved in cell contact.

Biological Process

Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Neuron recognitionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cell membrane

Involvement in disease

Ovarian cancer (OC):
The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Khamko, R., Wasenang, W., Daduang, J., Settasatian, C., & Limpaiboon, T. (2022). Combined OPCML and AXL expression as a prognostic marker and OPCML enhances AXL inhibitor in cholangiocarcinoma. in vivo, 36(3), 1168-1177.

Zhang, Y., Sun, X., Zhang, Y., Kang, Z., Cai, L., Ding, J., ... & Hu, G. (2022). GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients. Pharmacological Research, 184, 106459.

Shao, Y., Kong, J., Xu, H., Wu, X., Cao, Y., Li, W., ... & Wu, J. (2021). OPCML methylation and the risk of ovarian cancer: a meta and bioinformatics analysis. Frontiers in Cell and Developmental Biology, 9, 570898.

Antony, J., Zanini, E., Birtley, J. R., Gabra, H., & Recchi, C. (2021). Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers. Cancer Gene Therapy, 28(1), 18-26.

Lian, B., Li, H., Liu, Y., Chai, D., Gao, Y., Zhang, Y., ... & Li, J. (2021). Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer. Breast Cancer, 28, 448-458.

Fang, X., Dong, Y., Yang, R., & Wei, L. (2020). LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. Archives of biochemistry and biophysics, 689, 108390.

Simovic, I., Castaño-Rodríguez, N., & Kaakoush, N. O. (2019). OPCML: a promising biomarker and therapeutic avenue. Trends in Cancer, 5(8), 463-466.

Zhang, Z., Ye, M., Li, Q., You, Y., Yu, H., Ma, Y., ... & Zhang, D. (2019). The schizophrenia susceptibility gene OPCML regulates spine maturation and cognitive behaviors through Eph-Cofilin signaling. Cell Reports, 29(1), 49-61.

Wasenang, W., Chaiyarit, P., Proungvitaya, S., & Limpaiboon, T. (2019). Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases. Clinical Epigenetics, 11, 1-10.

Birtley, J. R., Alomary, M., Zanini, E., Antony, J., Maben, Z., Weaver, G. C., ... & Gabra, H. (2019). Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions. Nature communications, 10(1), 3134.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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