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Mouse Anti-OPCML (AA 28-322) Recombinant Antibody (CBXO-0381) (CBMAB-O0227-CQ)

This product is a mouse antibody that recognizes OPCML (AA 28-322). The antibody CBXO-0381 can be used for immunoassay techniques such as: WB.
See all OPCML antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0381
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant human OBCAM, Gly28-Asn322, Accession # Q14982
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 28-322

Target

Full Name
Opioid Binding Protein/Cell Adhesion Molecule Like
Introduction
This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily of proteins. The encoded preprotein is proteolytically processed to generate the mature protein. This protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Entrez Gene ID
4978
UniProt ID
Q14982
Alternative Names
Opioid Binding Protein/Cell Adhesion Molecule Like; IgLON Family Member 1; IGLON1; OBCAM; Opioid Binding Protein/Cell Adhesion Molecule-Like Preprotein; Opioid-Binding Protein/Cell Adhesion Molecule; Opioid-Binding Cell Adhesion Molecule; OPCM
Function
Binds opioids in the presence of acidic lipids; probably involved in cell contact.
Biological Process
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Neuron recognitionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Involvement in disease
Ovarian cancer (OC):
The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.

Khamko, R., Wasenang, W., Daduang, J., Settasatian, C., & Limpaiboon, T. (2022). Combined OPCML and AXL expression as a prognostic marker and OPCML enhances AXL inhibitor in cholangiocarcinoma. in vivo, 36(3), 1168-1177.

Zhang, Y., Sun, X., Zhang, Y., Kang, Z., Cai, L., Ding, J., ... & Hu, G. (2022). GPBAR1 preserves neurite and synapse of dopaminergic neurons via RAD21-OPCML signaling: Role in preventing Parkinson's disease in mouse model and human patients. Pharmacological Research, 184, 106459.

Shao, Y., Kong, J., Xu, H., Wu, X., Cao, Y., Li, W., ... & Wu, J. (2021). OPCML methylation and the risk of ovarian cancer: a meta and bioinformatics analysis. Frontiers in Cell and Developmental Biology, 9, 570898.

Antony, J., Zanini, E., Birtley, J. R., Gabra, H., & Recchi, C. (2021). Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers. Cancer Gene Therapy, 28(1), 18-26.

Lian, B., Li, H., Liu, Y., Chai, D., Gao, Y., Zhang, Y., ... & Li, J. (2021). Expression and promoter methylation status of OPCML and its functions in the inhibition of cell proliferation, migration, and invasion in breast cancer. Breast Cancer, 28, 448-458.

Fang, X., Dong, Y., Yang, R., & Wei, L. (2020). LINC00619 restricts gastric cancer progression by preventing microRNA-224-5p-mediated inhibition of OPCML. Archives of biochemistry and biophysics, 689, 108390.

Simovic, I., Castaño-Rodríguez, N., & Kaakoush, N. O. (2019). OPCML: a promising biomarker and therapeutic avenue. Trends in Cancer, 5(8), 463-466.

Zhang, Z., Ye, M., Li, Q., You, Y., Yu, H., Ma, Y., ... & Zhang, D. (2019). The schizophrenia susceptibility gene OPCML regulates spine maturation and cognitive behaviors through Eph-Cofilin signaling. Cell Reports, 29(1), 49-61.

Wasenang, W., Chaiyarit, P., Proungvitaya, S., & Limpaiboon, T. (2019). Serum cell-free DNA methylation of OPCML and HOXD9 as a biomarker that may aid in differential diagnosis between cholangiocarcinoma and other biliary diseases. Clinical Epigenetics, 11, 1-10.

Birtley, J. R., Alomary, M., Zanini, E., Antony, J., Maben, Z., Weaver, G. C., ... & Gabra, H. (2019). Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions. Nature communications, 10(1), 3134.

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For research use only. Not intended for any clinical use.

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