Sign in or Register   Sign in or Register
  |  

Mouse Anti-OPRL1 Recombinant Antibody (2A11) (CBMAB-O0492-CQ)

This product is a mouse antibody that recognizes OPRL1. The antibody 2A11 can be used for immunoassay techniques such as: ELISA.
See all OPRL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A11
Antibody Isotype
IgG2a, Κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
opiate receptor-like 1
Introduction
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Entrez Gene ID
4987
UniProt ID
P41146
Alternative Names
Opioid Related Nociceptin Receptor 1; Orphanin FQ Receptor; Nociceptin/Orphanin FQ Receptor; Kappa3-Related Opioid Receptor; Kappa-Type 3 Opioid Receptor; Opiate Receptor-Like 1; KOR-3; ORL1
Function
G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Conditioned place preferenceIEA:Ensembl
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of cAMP-mediated signalingIEA:Ensembl
Negative regulation of voltage-gated calcium channel activityIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Positive regulation of gastric acid secretionIEA:Ensembl
Positive regulation of sensory perception of painIEA:Ensembl
Positive regulation of urine volumeIEA:Ensembl
Regulation of locomotor rhythmIEA:Ensembl
Response to estradiolIEA:Ensembl
Sensory perceptionManual Assertion Based On ExperimentTAS:ProtInc
Sensory perception of painISS:UniProtKB
Cellular Location
Cell membrane
Cytoplasmic vesicle
Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.
Topology
Extracellular: 1-48
Helical: 49-74
Cytoplasmic: 75-87
Helical: 88-109
Extracellular: 110-124
Helical: 125-146
Cytoplasmic: 147-165
Helical: 166-188
Extracellular: 189-211
Helical: 212-236
Cytoplasmic: 237-264
Helical: 265-285
Extracellular: 286-300
Helical: 301-322
Cytoplasmic: 323-370
PTM
Phosphorylation at Ser-363 requires GRK3.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-OPRL1 Recombinant Antibody (2A11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare