OPRL1

The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

opiate receptor-like 1

G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Conditioned place preferenceIEA:Ensembl
Eating behaviorIEA:Ensembl
Estrous cycleIEA:Ensembl
G protein-coupled opioid receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwayIEA:Ensembl
Negative regulation of blood pressureIEA:Ensembl
Negative regulation of cAMP-mediated signalingIEA:Ensembl
Negative regulation of voltage-gated calcium channel activityIEA:Ensembl
Neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathwayManual Assertion Based On ExperimentIPI:UniProtKB
Positive regulation of gastric acid secretionIEA:Ensembl
Positive regulation of sensory perception of painIEA:Ensembl
Positive regulation of urine volumeIEA:Ensembl
Regulation of locomotor rhythmIEA:Ensembl
Response to estradiolIEA:Ensembl
Sensory perceptionManual Assertion Based On ExperimentTAS:ProtInc
Sensory perception of painISS:UniProtKB

Cell membrane
Cytoplasmic vesicle
Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-363. Can recycle to the cell membrane.

Extracellular: 1-48
Helical: 49-74
Cytoplasmic: 75-87
Helical: 88-109
Extracellular: 110-124
Helical: 125-146
Cytoplasmic: 147-165
Helical: 166-188
Extracellular: 189-211
Helical: 212-236
Cytoplasmic: 237-264
Helical: 265-285
Extracellular: 286-300
Helical: 301-322
Cytoplasmic: 323-370

Phosphorylation at Ser-363 requires GRK3.