Rabbit Anti-ORM2 Recombinant Antibody (CBXO-0147) (CBMAB-O0575-CQ)

This product is a rabbit antibody that recognizes ORM2. The antibody CBXO-0147 can be used for immunoassay techniques such as: WB, IHC-P.
See all ORM2 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBXO-0147

Antibody Isotype

IgG

Application

WB, IHC-P

Basic Information

Immunogen

A synthetic peptide corresponding to residues in human ORM1/2

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

49% PBS, 50% Glycerol, 0.05% BSA, pH 7.2

Preservative

0.01% Sodium Azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Orosomucoid 2

Introduction

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.

Entrez Gene ID

5005

UniProt ID

P19652

Alternative Names

AGP2; AGP-B; AGP-B'

Function

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Biological Process

Acute-phase responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune system processIEA:InterPro

Cellular Location

Secreted

PTM

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

References

Lee, S. H., Suh, J. H., Heo, M. J., Choi, J. M., Yang, Y., Jung, H. J., ... & Kim, K. H. (2024). The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids. Diabetes, db230520.

Wei, X., Wang, L., Yang, B., Ma, Y., Yuan, W., & Ma, J. (2024). Orosomucoid 2 upregulation mediates liver injury‐induced colorectal cancer liver metastasis by promoting EMT and cell migration. Cancer Science.

Li, L., Sun, H., Chen, J., Ding, C., Yang, X., Han, H., & Sun, Q. (2023). Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway. Cell Reports, 42(7).

Zhou, B., Luo, Y., Ji, N., Hu, C., & Lu, Y. (2022). Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis. Nature Metabolism, 4(9), 1185-1201.

Zhu, H. Z., Zhou, W. J., Wan, Y. F., Ge, K., Lu, J., & Jia, C. K. (2020). Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer. World journal of gastroenterology, 26(8), 804.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ORM2 Recombinant Antibody (CBXO-0410)

Mouse Anti-ORM2 Recombinant Antibody (CF322)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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