Human Recombinant ORM2 protein, His Tag (V2LY-0526-LY5879)

Name: Human Recombinant ORM2 protein, His Tag
SKU: V2LY-0526-LY5879
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ORM2 protein, His Tag consist of Amino Acid: 1-201 and predicts a molecular mass of 23.1 kDa.

Molecule Mass

23.1 kDa

Sequence

Amino Acid: 1-201

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Orosomucoid 2

Function

Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction.

Biological Process

Acute-phase responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of interleukin-1 beta productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of interleukin-1 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tumor necrosis factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of immune system processIEA:InterPro

Cellular Location

Secreted

PTM

N-glycosylated. N-glycan heterogeneity at Asn-33: Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).

Lee, S. H., Suh, J. H., Heo, M. J., Choi, J. M., Yang, Y., Jung, H. J., ... & Kim, K. H. (2024). The hepatokine orosomucoid 2 mediates beneficial metabolic effects of bile acids. Diabetes, db230520.

Wei, X., Wang, L., Yang, B., Ma, Y., Yuan, W., & Ma, J. (2024). Orosomucoid 2 upregulation mediates liver injury‐induced colorectal cancer liver metastasis by promoting EMT and cell migration. Cancer Science.

Li, L., Sun, H., Chen, J., Ding, C., Yang, X., Han, H., & Sun, Q. (2023). Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway. Cell Reports, 42(7).

Zhou, B., Luo, Y., Ji, N., Hu, C., & Lu, Y. (2022). Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis. Nature Metabolism, 4(9), 1185-1201.

Zhu, H. Z., Zhou, W. J., Wan, Y. F., Ge, K., Lu, J., & Jia, C. K. (2020). Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer. World journal of gastroenterology, 26(8), 804.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Orm2 ELISA Kit (CAT#: V2LY-0626-LY3324)

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Mouse Orm2 ELISA Kit (CAT#: V2LY-0626-LY3324)

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Rabbit Anti-ORM2 Recombinant Antibody (CBXO-0147) (CAT#: CBMAB-O0575-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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