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Mouse Anti-OSBPL3 Recombinant Antibody (CBXO-0348) (CBMAB-O0593-CQ)

This product is a mouse antibody that recognizes OSBPL3. The antibody CBXO-0348 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all OSBPL3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXO-0348
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Oxysterol Binding Protein Like 3
Introduction
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human26031
Mouse71720
Rat362360
UniProt ID
HumanQ9H4L5
MouseQ9DBS9
RatD3ZHZ3
Alternative Names
Oxysterol Binding Protein Like 3; OSBP-Related Protein 3; OSBP3; ORP-3; ORP3; Oxysterol-Binding Protein-Related Protein 3; Oxysterol Binding Protein-Like 3; KIAA0704
Function
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed:16143324).
Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed:25447204).
The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed:18270267, PubMed:25447204).
With VAPA, may regulate ER morphology (PubMed:16143324).
Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed:18270267).
Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed:16143324).
Also binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).
Biological Process
Bile acid biosynthetic processTAS:Reactome
Cellular Location
Endoplasmic reticulum membrane
Cytoplasm, cytosol
Cell membrane
Cell projection, filopodium tip
Nucleus membrane
Co-localizes with OSBPL6 at contact sites between the plasma membrane and the endoplasmic reticulum.
PTM
Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187 (PubMed:25447204).
Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion (PubMed:18270267).

Shan, S., Wang, X., Qian, L., Wang, C., & Zhao, S. (2024). ENST00000534735 inhibits proliferation and migration, promotes apoptosis and pyroptosis of endometrial cancer via OSBPL3 through APMK/SIRT1/NF-κB pathway. Heliyon, 10(4).

Xiang, L., & Su, Z. (2024). High-intensity interval training can inhibit of PPARγ/OSBPL3 pathway through epigenetic alterations in Non-Alcoholic Fatty Liver Disease. International Neurourology Journal, 28(1), 349-355.

Wang, C., He, Y., He, Y., Liang, W., Zhou, C., Wu, M., ... & Cao, J. (2023). Prognostic and biological function value of OSBPL3 in colorectal cancer analyzed by multi-omic data analysis. BMC gastroenterology, 23(1), 270.

Su, Y., Xue, C., Gu, X., Sun, Y., Zhang, R., & Li, L. (2023). Integrated bioinformatics analysis reveals the function and prognostic value of OSBPL3 in hepatocellular carcinoma. Heliyon, 9(6).

Zhang, M., Meng, L., Zhang, Z., Wu, J., Chen, X., Wang, Y., & He, J. (2022). The relationships of OSBPL3 expression with KI-67 expression and KRAS mutations in CRC: implications for diagnosis and prognosis. BMC Medical Genomics, 15(1), 259.

Zhang, M., Meng, L., Zhang, Z., Wu, J., Chen, X., & He, J. (2022). The respective relations of expression of OSBPL3 with Ki-67 expression and KRAS mutation in CRC for diagnosis and prognosis.

Hu, Q., Masuda, T., Koike, K., Sato, K., Tobo, T., Kuramitsu, S., ... & Mimori, K. (2021). Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer. Scientific reports, 11(1), 19178.

Hao, N., Zhou, Y., Li, Y., Zhang, H., Wang, B., Liu, X., ... & Tang, X. (2021). Clinical value and potential mechanisms of oxysterol-binding protein like 3 (OSBPL3) in human tumors. Frontiers in Molecular Biosciences, 8, 739978.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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