Mouse Anti-OSBPL7 Recombinant Antibody (CBXO-0334) (CBMAB-O0595-CQ)

Name: Mouse Anti-OSBPL7 Recombinant Antibody (CBXO-0334)
SKU: CBMAB-O0595-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXO-0334

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

oxysterol binding protein-like 7

Introduction

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding the same isoform have been identified.

Entrez Gene ID

114881

UniProt ID

Q9BZF2

Alternative Names

Oxysterol Binding Protein Like 7; OSBP-Related Protein 7; ORP-7; ORP7; Oxysterol-Binding Protein-Related Protein 7; Oxysterol Binding Protein-Like 7

Biological Process

Bile acid biosynthetic processTAS:Reactome
Cellular response to cholesterolManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of proteasomal protein catabolic processManual Assertion Based On ExperimentIMP:BHF-UCL
Regulation of autophagy1 PublicationNAS:ParkinsonsUK-UCL

Cellular Location

Cytoplasm, cytosol
Endoplasmic reticulum membrane
Cell membrane

Wright, M. B., Varona Santos, J., Kemmer, C., Maugeais, C., Carralot, J. P., Roever, S., ... & Fornoni, A. (2021). Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nature communications, 12(1), 4662.

Wang, M. (2021). Targeting OSBPL7 restores cholesterol efflux. Nature Reviews Nephrology, 17(11), 707-707.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-OSBPL7 (AA 742-842) Recombinant Antibody (3D11) (CAT#: CBMAB-O0594-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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