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Mouse Anti-OSM Recombinant Antibody (CBXO-0290) (CBMAB-O0441-CQ)

This product is a mouse antibody that recognizes OSM. The antibody CBXO-0290 can be used for immunoassay techniques such as: ELISA, Neut, WB.
See all OSM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXO-0290
Antibody Isotype
IgG2a
Application
ELISA, Neut, WB

Basic Information

Immunogen
Recombinant full length human Oncostatin M protein expressed in E. coli. Cellular Localization: Secreted
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Oncostatin M
Introduction
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Entrez Gene ID
5008
UniProt ID
P13725
Alternative Names
Oncostatin M; Oncostatin-M
Function
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Biological Process
Immune responseIEA:InterPro
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:CACAO
Regulation of growthIEA:UniProtKB-KW
Regulation of hematopoietic stem cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Cellular Location
Secreted
PTM
Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.

Hioki, T., Tachi, J., Ueda, K., Matsushima‑Nishiwaki, R., Iida, H., Kozawa, O., & Tokuda, H. (2024). Oncostatin M enhances osteoprotegerin synthesis but reduces macrophage colony‑stimulating factor synthesis in bFGF‑stimulated osteoblast‑like cells. Experimental and Therapeutic Medicine, 27(1), 1-9.

Polak, K. L., Tamagno, I., Parameswaran, N., Smigiel, J., Chan, E. R., Yuan, X., ... & Jackson, M. W. (2023). Oncostatin-M and OSM-Receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs. Molecular Cancer Research, 21(9), 975-990.

Yang, X., Shao, C., Duan, L., Hou, X., Huang, Y., Gao, L., ... & Wei, L. (2021). Oncostatin M promotes hepatic progenitor cell activation and hepatocarcinogenesis via macrophage-derived tumor necrosis factor-α. Cancer Letters, 517, 46-54.

Verstockt, S., Verstockt, B., Machiels, K., Vancamelbeke, M., Ferrante, M., Cleynen, I., ... & Vermeire, S. (2021). Oncostatin M is a biomarker of diagnosis, worse disease prognosis, and therapeutic nonresponse in inflammatory bowel disease. Inflammatory bowel diseases, 27(10), 1564-1575.

Tseng, P. Y., & Hoon, M. A. (2021). Oncostatin M can sensitize sensory neurons in inflammatory pruritus. Science translational medicine, 13(619), eabe3037.

Masjedi, A., Hajizadeh, F., Dargani, F. B., Beyzai, B., Aksoun, M., Hojjat-Farsangi, M., ... & Jadidi-Niaragh, F. (2021). Oncostatin M: A mysterious cytokine in cancers. International Immunopharmacology, 90, 107158.

Chen, M., Ren, R., Lin, W., Xiang, L., Zhao, Z., & Shao, B. (2021). Exploring the oncostatin M (OSM) feed-forward signaling of glioblastoma via STAT3 in pan-cancer analysis. Cancer cell international, 21, 1-19.

Piquer-Garcia, I., Campderros, L., Taxerås, S. D., Gavaldà-Navarro, A., Pardo, R., Vila, M., ... & Sánchez-Infantes, D. (2020). A role for oncostatin M in the impairment of glucose homeostasis in obesity. The Journal of Clinical Endocrinology & Metabolism, 105(3), e337-e348.

Houben, E., Hellings, N., & Broux, B. (2019). Oncostatin M, an underestimated player in the central nervous system. Frontiers in immunology, 10, 455653.

Stawski, L., & Trojanowska, M. (2019). Oncostatin M and its role in fibrosis. Connective tissue research, 60(1), 40-49.

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For research use only. Not intended for any clinical use.

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