OSM
This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Full Name
Oncostatin M
Function
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).
Biological Process
Immune responseIEA:InterPro
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:CACAO
Regulation of growthIEA:UniProtKB-KW
Regulation of hematopoietic stem cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:CACAO
Regulation of growthIEA:UniProtKB-KW
Regulation of hematopoietic stem cell differentiationManual Assertion Based On ExperimentTAS:GO_Central
Cellular Location
Secreted
PTM
Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.
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Anti-OSM antibodies
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CompareTarget: OSM
Host: Mouse
Specificity: Human
Clone: CBXO-0083
Application*: WB, IC, P, C, E
Target: OSM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0082
Application*: E, WB
Target: OSM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B6
Application*: IH, P, WB
Target: OSM
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXO-0240
Application*: WB
Target: OSM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXO-0239
Application*: N, WB
Target: OSM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXO-0172
Application*: E
Target: OSM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0175
Application*: E
Target: OSM
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0490
Application*: WB, N
Target: OSM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0290
Application*: E, N, WB
Target: OSM
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXO-0466
Application*: E
Target: OSM
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBXO-0564
Application*: N, WB
Target: OSM
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXO-0398
Application*: N
Target: OSM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0363
Application*: N, IS, MC
Target: OSM
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 17001.31
Application*: WB, E, IH, P, N
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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