OSM

This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Oncostatin M

Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity).

Immune responseIEA:InterPro
Multicellular organism developmentManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of hormone secretionManual Assertion Based On ExperimentIDA:MGI
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell divisionIEA:UniProtKB-KW
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of inflammatory responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of MAPK cascadeManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:MGI
Positive regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIGI:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIDA:CACAO
Regulation of growthIEA:UniProtKB-KW
Regulation of hematopoietic stem cell differentiationManual Assertion Based On ExperimentTAS:GO_Central

Secreted

Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity.