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Rat Anti-OSMR (AA 24-738) Recombinant Antibody (CBXO-0206) (CBMAB-O0001-CQ)

This product is a rat antibody that recognizes OSMR (AA 24-738). The antibody CBXO-0206 can be used for immunoassay techniques such as: WB, FC, ICC, CyTOF.
See all OSMR antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXO-0206
Antibody Isotype
IgG2a
Application
WB, FC, ICC, CyTOF

Basic Information

Immunogen
Recombinant mouse OSM R beta, Glu24-Leu738, Accession # O70458
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS and NaCl with Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 24-738

Target

Full Name
Oncostatin M Receptor
Introduction
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
18414
UniProt ID
O70458
Alternative Names
Oncostatin M Receptor; Interleukin-31 Receptor Subunit Beta; IL-31 Receptor Subunit Beta; IL-31R Subunit Beta; IL-31R-Beta; IL-31RB
Function
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIGI:BHF-UCL
Response to cytokineManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Amyloidosis, primary localized cutaneous, 1 (PLCA1):
A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.
Topology
Extracellular: 28-740
Helical: 741-761
Cytoplasmic: 762-979

Polak, K. L., Tamagno, I., Parameswaran, N., Smigiel, J., Chan, E. R., Yuan, X., ... & Jackson, M. W. (2023). Oncostatin-M and OSM-Receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs. Molecular Cancer Research, 21(9), 975-990.

Geng, Q., Wang, J., Zhang, W., Zhou, W., Tang, G., & Gu, M. (2023). Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis. Journal of Oral Pathology & Medicine, 52(2), 136-144.

Geethadevi, A., Tsaih, S. W., Nair, A., Ku, Z., Kadamberi, I. P., Parashar, D., ... & Raghavan, P. C. (2023). Oncostatin m receptor signaling reprograms tumor microenvironment for chemoresistance. Cancer Research, 83(7_Supplement), 3653-3653.

Zhou, J., Yang, J., Dong, Y., Shi, Y., Zhu, E., Yuan, H., ... & Wang, B. (2022). Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling. Stem Cell Research & Therapy, 13(1), 278.

Geethadevi, A., Nair, A., Parashar, D., Ku, Z., Xiong, W., Deng, H., ... & Chaluvally-Raghavan, P. (2021). Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. Cancer research, 81(20), 5336-5352.

Houben, E., Hellings, N., & Broux, B. (2019). Oncostatin M, an underestimated player in the central nervous system. Frontiers in immunology, 10, 455653.

Yu, Z., Li, Z., Wang, C., Pan, T., Chang, X., Wang, X., ... & Su, L. (2019). Oncostatin M receptor, positively regulated by SP1, promotes gastric cancer growth and metastasis upon treatment with Oncostatin M. Gastric Cancer, 22, 955-966.

Guo, Q., Guan, G. F., Cao, J. Y., Zou, C. Y., Zhu, C., Cheng, W., ... & Wu, A. H. (2019). Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. Journal of Cellular Physiology, 234(9), 15496-15509.

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For research use only. Not intended for any clinical use.

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