OSMR Antibodies

Structure of OSMR

The molecular weight of the protein encoded by the OSMR gene is approximately 100-110 kDa, and this value fluctuates to some extent under different splicing variants or post-translational modification states.

The OSMR protein (tumor suppressant M receptor β chain) belongs to the type I cytokine receptor family. Its primary structure contains multiple conserved extracellular fibronectin type III domains, which are responsible for binding to ligands such as tumor suppressant M or interleukin-31. The transmembrane region of the protein anchors it to the cell membrane, while the intracellular region is responsible for recruiting and activating JAK kinases, thereby initiating the downstream JAK-STAT signaling pathway. Its secondary structure is mainly composed of β -folds, which form the domain framework necessary for ligand binding.

Fig. 1 OSMR signaling in Glioma Stem Cells.¹

Key structural properties of OSMR:

• Extracellular section contains multiple fiber connection protein III structure domain
• Transmembrane domains maintain the stable anchoring of receptors on the cell membrane
• Intracellular period of conservative Box1 / Box2 motif
• Glycosylation modification sites affect protein stability and signal transduction efficiency

Functions of OSMR

The main function of the tumor suppressant M receptor β chain encoded by the OSMR gene is to mediate cytokine signal transduction and participate in regulating cell proliferation, differentiation and inflammatory responses. The specific functions are as follows

Unlike single-function oxygen storage proteins, the signaling network mediated by OSMR is pleiotropic, and its activation can trigger diverse downstream biological effects depending on cell type and microenvironment differences.

Applications of OSMR and OSMR Antibody in Literature

• Lee, Brian Y., et al. "Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis." Nature communications 12.1 (2021): 7336. https://doi.org/10.1038/s41467-021-27607-8 

The article indicates that OSM secreted by macrophages activates cancer-associated fibroblasts through OSMR signaling, reshapes the pancreatic cancer microenvironment, promotes tumor growth and metastasis, and suppresses immune responses. OSM deficiency slows down the tumor progression and enhances anti-tumor immunity.

• Lantieri, Francesca, and Tiziana Bachetti. "OSM/OSMR and interleukin 6 family cytokines in physiological and pathological condition." International Journal of Molecular Sciences 23.19 (2022): 11096. https://doi.org/10.3390/ijms231911096  

The article indicates that OSM is a multifunctional interleukin-6 family cytokine, which activates multiple signaling pathways such as JAK/STAT and MAPK through receptors like OSMR, and plays a key regulatory role in various physiological and pathological processes such as fat metabolism, myocardial repair, bone balance and intestinal inflammation.

• Mohan, Sushmetha, Azad Bonni, and Arezu Jahani-Asl. "Targeting OSMR in glioma stem cells." Oncotarget 8.10 (2017): 16103. https://doi.org/10.18632/oncotarget.15066

The article indicates that in glioblastoma, the OSMR receptor upregulated by EGFRvIII is the key to the proliferation and tumorigenesis of tumor stem cells. Targeting OSMR or interfering with its interaction with EGFRvIII is expected to become a potential new therapeutic strategy.

• Schwartz, Logan S., et al. "Characterization of an Osmr Conditional Knockout Mouse Model." bioRxiv (2023). https://doi.org/10.1101/2023.10.27.564474 

The article indicates that studies using the Osmr conditional knockout mouse model have found that the deletion of exon 2 has tissue-differential effects on the transcription and protein expression of the Osmr gene, suggesting that this model needs to be carefully evaluated in application.

• Feng, Yizhou, et al. "OSMR deficiency aggravates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signalling." Journal of Translational Medicine 21.1 (2023): 290. https://doi.org/10.1186/s12967-023-04163-x

This article describes a rare case of primary multiple pleomorphic rhabdomyosarcoma in a dog's heart, where myoglobin antibody was used as an immunohistochemical marker to confirm the tumor's myogenic origin, demonstrating its diagnostic significance in differentiating cardiac neoplasms.

Creative Biolabs: OSMR Antibodies for Research

Creative Biolabs specializes in the production of high-quality OSMR antibodies for research and industrial applications. Our portfolio includes monoclonal antibodies tailored for ELISA, Flow Cytometry, Western blot, immunohistochemistry, and other diagnostic methodologies.

• Custom OSMR Antibody Development: Tailor-made solutions to meet specific research requirements.
• Bulk Production: Large-scale antibody manufacturing for industry partners.
• Technical Support: Expert consultation for protocol optimization and troubleshooting.
• Aliquoting Services: Conveniently sized aliquots for long-term storage and consistent experimental outcomes.

For more details on our OSMR antibodies, custom preparations, or technical support, contact us at email.