Rabbit Anti-OSMR Recombinant Antibody (CBXO-0062) (CBMAB-O0445-CQ)

Name: Rabbit Anti-OSMR Recombinant Antibody (CBXO-0062)
SKU: CBMAB-O0445-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXO-0062

Application

ELISA, WB

Immunogen

Recombinant Human OSMRIL-31RB Protein

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Oncostatin M Receptor

Introduction

This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

9180

UniProt ID

Q99650

Alternative Names

Oncostatin M Receptor; Interleukin-31 Receptor Subunit Beta; IL-31 Receptor Subunit Beta; IL-31R Subunit Beta; IL-31R-Beta; IL-31RB

Function

Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Oncostatin-M-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of acute inflammatory response1 PublicationIC:BHF-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIGI:BHF-UCL
Response to cytokineManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Membrane

Involvement in disease

Amyloidosis, primary localized cutaneous, 1 (PLCA1):
A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

Topology

Extracellular: 28-740
Helical: 741-761
Cytoplasmic: 762-979

Polak, K. L., Tamagno, I., Parameswaran, N., Smigiel, J., Chan, E. R., Yuan, X., ... & Jackson, M. W. (2023). Oncostatin-M and OSM-Receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs. Molecular Cancer Research, 21(9), 975-990.

Geng, Q., Wang, J., Zhang, W., Zhou, W., Tang, G., & Gu, M. (2023). Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis. Journal of Oral Pathology & Medicine, 52(2), 136-144.

Geethadevi, A., Tsaih, S. W., Nair, A., Ku, Z., Kadamberi, I. P., Parashar, D., ... & Raghavan, P. C. (2023). Oncostatin m receptor signaling reprograms tumor microenvironment for chemoresistance. Cancer Research, 83(7_Supplement), 3653-3653.

Zhou, J., Yang, J., Dong, Y., Shi, Y., Zhu, E., Yuan, H., ... & Wang, B. (2022). Oncostatin M receptor regulates osteoblast differentiation via extracellular signal-regulated kinase/autophagy signaling. Stem Cell Research & Therapy, 13(1), 278.

Geethadevi, A., Nair, A., Parashar, D., Ku, Z., Xiong, W., Deng, H., ... & Chaluvally-Raghavan, P. (2021). Oncostatin M Receptor–Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth. Cancer research, 81(20), 5336-5352.

Houben, E., Hellings, N., & Broux, B. (2019). Oncostatin M, an underestimated player in the central nervous system. Frontiers in immunology, 10, 455653.

Yu, Z., Li, Z., Wang, C., Pan, T., Chang, X., Wang, X., ... & Su, L. (2019). Oncostatin M receptor, positively regulated by SP1, promotes gastric cancer growth and metastasis upon treatment with Oncostatin M. Gastric Cancer, 22, 955-966.

Guo, Q., Guan, G. F., Cao, J. Y., Zou, C. Y., Zhu, C., Cheng, W., ... & Wu, A. H. (2019). Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. Journal of Cellular Physiology, 234(9), 15496-15509.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

OSMR Matched Antibody Pair (836) (CAT#: APMAB-836LY)

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Isotype control

For research use only. Not intended for any clinical use.

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