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Mouse Anti-OXSR1 Recombinant Antibody (5G8) (CBMAB-0796-CN)

This product is a mouse antibody that recognizes OXSR1 of human. The antibody 5G8 can be used for immunoassay techniques such as: ELISA, MA.
See all OXSR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5G8
Antibody Isotype
IgG2a
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein of OXSR1
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Oxidative Stress Responsive 1
Introduction
The product of OXSR1 belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton.
Entrez Gene ID
9943
UniProt ID
O95747
Alternative Names
OSR1
Function
Phosphorylates RELL1, RELL2 and RELT (PubMed:16389068, PubMed:28688764).
Phosphorylates PAK1 (PubMed:14707132).
Phosphorylates PLSCR1 in the presence of RELT (PubMed:22052202).
Biological Process
Cellular hypotonic responseIEA:Ensembl
Cellular response to chemokineManual Assertion Based On ExperimentIMP:BHF-UCL
Chemokine (C-C motif) ligand 21 signaling pathwayBy SimilarityISS:BHF-UCL
Chemokine (C-X-C motif) ligand 12 signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of potassium ion transmembrane transporter activityIEA:Ensembl
Osmosensory signaling pathwayManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Peptidyl-threonine phosphorylationManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Positive regulation of T cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Protein autophosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Cellular Location
Cytoplasm
PTM
Autophosphorylated.

Li, P., Liu, Y., & You, T. (2023). CircNRIP1 knockdown alleviates Lipopolysaccharide-induced human kidney 2 cell apoptosis and inflammation through miR-339-5p/OXSR1 pathway. Shock, 59(3), 426-433.

Lei, C., Huo, Y., Ma, F., Liao, J., Hu, Z., Han, Q., ... & Tang, Z. (2023). Long-term copper exposure caused hepatocytes autophagy in broiler via miR-455-3p-OXSR1 axis. Chemico-Biological Interactions, 369, 110256.

Yang, Q., Sun, Q., & Jin, P. (2022). Long non‑coding RNA PVT1 regulates LPS‑induced acute kidney injury in an in vitro model of HK‑2 cells by modulating the miR‑27a‑3p/OXSR1 axis. Experimental and Therapeutic Medicine, 24(3), 1-10.

Chu, J., Geng, G., Ai, X., Jia, W., Wang, J., Xu, B., ... & Kong, L. (2022). LINC01291 promotes hepatocellular carcinoma development by targeting the miR‐186‐5p/OXSR1 axis. The Journal of Gene Medicine, 24(2), e3394.

Cui, H., Ren, G., Hu, X., Xu, B., Li, Y., Niu, Z., & Mu, L. (2022). Suppression of lncRNA GAS6-AS2 alleviates sepsis-related acute kidney injury through regulating the miR-136-5p/OXSR1 axis in vitro and in vivo. Renal Failure, 44(1), 1071-1083.

Wu, W., Zhong, W., Xu, Q., & Yan, J. (2022). Silencing of long non-coding RNA ZFAS1 alleviates LPS-induced acute lung injury by mediating the miR-96-5p/OXSR1 axis in sepsis. The American Journal of the Medical Sciences, 364(1), 66-75.

Li, H., Zhang, X., Wang, P., Zhou, X., Liang, H., & Li, C. (2021). Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury. Diabetology & metabolic syndrome, 13, 1-14.

Li, R., Wen, Y., Wu, B., He, M., Zhang, P., Zhang, Q., & Chen, Y. (2020). MicroRNA-25-3p suppresses epileptiform discharges through inhibiting oxidative stress and apoptosis via targeting OXSR1 in neurons. Biochemical and Biophysical Research Communications, 523(4), 859-866.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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