Sign in or Register   Sign in or Register
  |  

Mouse Anti-PALLD Recombinant Antibody (CBCNC-674) (CBMAB-C4044-CN)

This product is a Mouse antibody that recognizes PALLD. The antibody CBCNC-674 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all PALLD antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNC-674
Application
WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Immunogen
Palladin
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Palladin, Cytoskeletal Associated Protein
Introduction
This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Entrez Gene ID
23022
UniProt ID
Q8WX93
Alternative Names
Palladin, Cytoskeletal Associated Protein; Sarcoma Antigen NY-SAR-77; SIH002; Myoneurin; Palladin; KIAA0992;
Function
Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.
Biological Process
Actin cytoskeleton organizationIEA:Ensembl
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationIEA:InterPro
Cytoskeleton organization1 PublicationNAS:HGNC-UCL
Dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Epithelial cell morphogenesisIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Keratinocyte developmentIEA:Ensembl
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Cytoplasm, myofibril, sarcomere, Z line
Cell projection, ruffle
Cell projection, podosome
Cell projection, lamellipodium
Cell projection, axon
Cell projection, growth cone
Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434).
Preferentially expressed in the excitatory presynaptic terminals (By similarity).
Involvement in disease
Pancreatic cancer 1 (PNCA1):
A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.
PTM
Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity).
Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-PALLD Recombinant Antibody (CBCNC-674)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare