Mouse Anti-PALLD Recombinant Antibody (CBCNC-674) (CBMAB-C4044-CN)

Name: Mouse Anti-PALLD Recombinant Antibody (CBCNC-674)
SKU: CBMAB-C4044-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBCNC-674

Application

WB, ICC, IHC-P, IHC-F, ELISA

Immunogen

Palladin

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

Palladin, Cytoskeletal Associated Protein

Introduction

This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in this gene are associated with a susceptibility to pancreatic cancer type 1, and also with a risk for myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Entrez Gene ID

23022

UniProt ID

Q8WX93

Alternative Names

Palladin, Cytoskeletal Associated Protein; Sarcoma Antigen NY-SAR-77; SIH002; Myoneurin; Palladin; KIAA0992;

Function

Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation. Involved in targeting ACTN to specific subcellular foci.

Biological Process

Actin cytoskeleton organizationIEA:Ensembl
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Cell migrationIEA:InterPro
Cytoskeleton organization1 PublicationNAS:HGNC-UCL
Dendrite self-avoidanceManual Assertion Based On ExperimentIBA:GO_Central
Epithelial cell morphogenesisIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesManual Assertion Based On ExperimentIBA:GO_Central
Keratinocyte developmentIEA:Ensembl

Cellular Location

Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Cytoplasm, myofibril, sarcomere, Z line
Cell projection, ruffle
Cell projection, podosome
Cell projection, lamellipodium
Cell projection, axon
Cell projection, growth cone
Localizes to stress fibers and Z lines (PubMed:11598191, PubMed:16125169, PubMed:17322171, PubMed:17537434).
Preferentially expressed in the excitatory presynaptic terminals (By similarity).

Involvement in disease

Pancreatic cancer 1 (PNCA1):
A malignant neoplasm of the pancreas. Tumors can arise from both the exocrine and endocrine portions of the pancreas, but 95% of them develop from the exocrine portion, including the ductal epithelium, acinar cells, connective tissue, and lymphatic tissue.

PTM

Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines (By similarity).
Phosphorylation at Ser-1118 by PKB/AKT1 modulates cytoskeletal organization and cell motility.

Huang, Z., Zeng, Z., Li, J., Cai, R., He, W., & Hu, S. (2023). High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 43(8), 1371-1378.

Zhang, Y., Li, J., Qi, H., & Kong, X. (2022). Mechanisms of PALLD, PRKCH, AKAP12, PDK4, and CHIT1 Proteins in Serum Diagnosis of Neonatal Sepsis. Clinical Laboratory, 68(11).

Liu, X., Xu, S., Li, Y., Chen, Q., Zhang, Y., & Peng, L. (2021). Identification of CALU and PALLD as potential biomarkers associated with immune infiltration in heart failure. Frontiers in Cardiovascular Medicine, 8, 774755.

Liotta, L., Lange, S., Maurer, H. C., Olive, K. P., Braren, R., Pfarr, N., ... & Quante, M. (2021). PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer. JCI insight, 6(8).

Li, L., Cheng, X., Chen, L., Li, J., Luo, W., & Li, C. (2019). Long noncoding ribonucleic acid MSTRG. 59589 promotes porcine skeletal muscle satellite cells differentiation by enhancing the function of PALLD. Frontiers in genetics, 10, 496037.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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