Mouse Anti-PANX2 Recombinant Antibody (12K156) (CBMAB-P0737-YC)

Name: Mouse Anti-PANX2 Recombinant Antibody (12K156)
SKU: CBMAB-P0737-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

12K156

Application

Immunogen

Recombinant corresponding to aa316-456 from human Pannexin-2 expressed in E. coli

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 316-456

More Infomation

Target

Full Name

pannexin 2

Introduction

PANX2 belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties.

Entrez Gene ID

56666

UniProt ID

Q96RD6

Alternative Names

Pannexin 2; Pannexin-2; HPANX2; PX2;

Function

Structural component of the gap junctions and the hemichannels.

Biological Process

Cation transportManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell signalingManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interleukin-1 productionIEA:InterPro
Response to ischemiaIEA:Ensembl

Cellular Location

Cell membrane
Cell junction, gap junction

Topology

Cytoplasmic: 11-47
Helical: 48-70
Extracellular: 71-123
Helical: 124-146
Cytoplasmic: 147-226
Helical: 227-249
Extracellular: 250-292
Helical: 293-315
Cytoplasmic: 316-643

Xu, X., Hao, Y., Xiong, S., & He, Z. (2021). PANX2 and brain lower grade glioma genesis: a bioinformatic analysis. Science Progress, 104(2), 00368504211011836.

Ray, S. L., Coulson, D. J., Yeoh, M. L. Y., Tamara, A., Latief, J. S., Bakhashab, S., & Weaver, J. U. (2020). The role of miR-342 in vascular health. Study in subclinical cardiovascular disease in mononuclear cells, plasma, inflammatory cytokines and PANX2. International Journal of Molecular Sciences, 21(19), 7217.

Kim, K. M., Hussein, U. K., Bae, J. S., Park, S. H., Kwon, K. S., Ha, S. H., ... & Jang, K. Y. (2019). The expression patterns of FAM83H and PANX2 are associated with shorter survival of clear cell renal cell carcinoma patients. Frontiers in oncology, 9, 14.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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